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| Correlation Analysis of Serum EGF YKL-40 SAA Levels and Cognitive Impairment of Patients with Parkinson's Disease |
| SUN Ni, SHI Jing, LIU Gui'an |
| Dandong Central Hospital, Liaoning Dandong 118002, China |
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Abstract Objective: To explore the correlation between the level of serum human cartilage glycoprotein 39 (YKL-40), epidermal growth factor (EGF), amyloid A (SAA) and cognitive impairment of patients with Parkinson's disease (PD). Methods: A total of 62 PD patients admitted to our hospital from May 2019 to May 2020 were selected as the observation group, and 60 healthy controls during the same period for physical examination were selected as the control group. Analyze the serum YKL-40, EGF, and SAA levels of the observation group and the control group, the Montreal Cognitive Assessment Scale (MoCA) score, and record the observation group’s Parkinson’s disease unified score scale (UPDRS) score. Pearson was used to analyze the correlation between UPDRS score, MoCA score and serum YKL-40, EGF, SAA levels in PD patients. Results: The serum YKL-40, EGF and SAA levels of the observation group were significantly higher than those of the control group, and the MoCA score was significantly lower than that of the control group. There was a statistical difference between the two groups (P<0.05). The condition of patients in the observation group was recorded, including UPDRS Ⅰ (3.84 ± 0.47) points, UPDRS Ⅱ (23.83 ± 3.07) points, and UPDRS Ⅲ (29.9 ± 3.49) points. Pearson was used to analyze the correlation between UPDRS score, MoCA score and serum YKL-40, EGF, SAA levels in PD patients, and the results showed that serum YKL-40、EGF, SAA levels were negatively correlated with MoCA score (r = -0.425, -0.548,- 0.455, P<0.01), and UPDRSⅠ (r=0.604, 0.645, 0.592, P<0.01), UPDRSⅡ (r=0.559, 0.527, 0.636, P<0.01), UPDRSⅢ (r=0.584, 0.709, 0.613, P<0.01) 0.01). The scores were positively correlated. Conclusion: The levels of serum YKL-40, EGF and SAA in PD patients are significantly increased, and are closely related to the patient's condition and cognitive impairment. The index levels have certain reference value for clinical early detection and treatment.
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2021, Vol. 27 
