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| Changes of Serum MBL Masp-2 and DKK-1 Levels in Patients with Rheumatoid Arthritis and Their Correlation with Prognosis |
| ZANG Xuelian, JU Yanling, ZHAO Xu |
| Jinzhou Central Hospital, Liaoning Jinzhou 121000, China |
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Abstract Objective: To study the changes of levels of serum mannose-binding lectin (MBL), MBL-associated serine protease-2 (MASP-2) and Dickkopf-1 protein (DKK-1) in patients with rheumatoid arthritis (RA) and their correlation with prognosis of patients. Methods: 194 RA patients and 102 health examiners in our hospital from August 2017 to August 2020 were selected as the study group and the control group. Serum MBL, masp-2 and DKK-1 levels were detected at admission. According to 28 joint disease activity scores (DAS28), the patients were divided into mild group (n = 83), moderate group (n = 62) and severe group (n = 49). According to the guidelines, RA patients were given standard treatment. According to the efficacy, the patients were divided into standard group (n = 129) and standard group (n = 65), The serum levels of MBL, masp-2 and DKK-1 were compared in each group, and their influence on DAS28 score and predictive value for curative effect were analyzed. Results: The levels of serum MBL and MASP-2 in study group were lower than those in control group, while the level of serum DKK-1 was higher than that in control group. The levels of serum MBL and MASP-2 in mild, moderate and severe groups were gradually decreased, while the level of serum DKK-1 and DAS28 score were gradually increased. The levels of serum MBL and MASP-2 in standard group were higher than those in non-standard group, while the level of serum DKK-1 was lower than that in non-standard group (P<0.05). Multivariate linear regression analysis showed that the levels of serum MBL and MASP-2 were important factors affecting the DAS28 score (P<0.05). Serum MBL and MASP-2 levels were closely related to the treatment effect of RA, and logistics regression model of substandard RA treatment was shown as Y=12.573-0.722× serum MBL-0.090× serum MASP-2+0.792× serum DKK-1. The AUC values of serum MBL, MASP-2, DKK-1 and the combined detection of the three in predicting the efficacy of RA were 0.896, 0.825, 0.693 and 0.958 respectively, and the sensitivities were 72.09%, 67.44%, 80.62% and 89.15%, and the specificities were 90.77%, 81.54%, 52.31% and 90.77%. Conclusion: The levels of MBL and masp-2 in serum of RA patients were significantly decreased, while the level of DKK-1 in serum was significantly increased, which was closely related to the changes of the disease, and could provide reference information for the evaluation of curative effect and prognosis.
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2021, Vol. 27 
