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| Efficacy of Levonorgestrel Intrauterine Sustained-Release System in the Treatment of Endometrial Hyperplasia |
| CUI Guanqun |
| Pingquan Hospital, Hebei Pingquan 067500, China |
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Abstract Objective: To explore the efficacy of levonorgestrel intrauterine sustained-release system(LNG-IUS)in the treatment of endometrial hyperplasia. Methods: A total of 260 patients with endometrial hyperplasia admitted in our hospital from April 2019 to April 2020 were selected. The selected patients met the inclusion criteria and were randomly divided into two groups, each with 130 cases. During treatment, medroxyprogesterone acetate was administered to the control group, and LNG-IUS was administered to the observation group. The curative effect was compared through 3 menstrual periods. Results: Before treatment, there was no difference in endometrial thickness and hemoglobin level between the two groups(P>0.05);After treatment, the endometrial thickness and hemoglobin level of the observation group were better than those of the control group(P<0.05).Before treatment, there was no difference in the scores of PBAC, menstrual volume and progesterone receptor between the two groups(P>0.05); After treatment, PBAC, progesterone receptor score and menstrual volume of the observation group were better than those of the control group(P<0.05).The levels of E2(estradiol),P(progesterone),LH(luteinizing hormone) and FSH(serum follicle stimulating hormone)in the observation group were significantly different before and after treatment(P<0.05),with statistical significance; The levels of E2(estradiol),P(progesterone),LH(luteinizing hormone)and FSH(serum follicle stimulating hormone)in the control group were not significantly different before and after treatment(P>0.05).During the treatment period, the LNG-IUS of 3 patients in the observation group fell off due to excessive menstruation,26 cases had abnormal vaginal bleeding,1 case was taken out midway, and 3 cases were closed; In the control group,4 patients had poor symptom control and 6 patients were diagnosed with pregnancy; During the treatment, there were no coagulation, renal and liver dysfunction in both groups. Conclusion: The choice of LNG-IUS for the treatment of endometrial hyperplasia has a definite curative effect and can effectively regulate the level of progesterone, thereby implementing effective treatment for endometrial hyperplasia, which is worthy of promotion.
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[1] 于健.醋酸甲羟孕酮治疗非典型子宫内膜增生的疗效观察[J].中国生化药物杂志,2015,(4):129~131.
[2] 李楠,徐翠,贺丰杰,等.宫腔灌注中药复方凋膜止崩液治疗子宫内膜增生症大鼠的效果及对子宫内膜相关因子表达的影响[J].广西医学,2018,40(9):1057~1060.
[3] 谢凤云,徐隽颖,蔡喆,等.子宫内膜内皮素与左炔诺孕酮宫内缓释系统治疗子宫内膜增生症后子宫异常出血的关系[J].广东医学,2015,(4):626~627.
[4] 林营.探讨左炔诺孕酮宫内释放系统治疗子宫内膜增生伴多囊卵巢综合征的临床疗效[J].中国实用医药,2018,13(18):130~131.
[5] 卜春艳,王素影,索青霞,等.左炔诺孕酮治疗子宫内膜增生症的效果及作用机制研究[J].河北医药,2019,41(15):2346~2348,2352.
[6] 张素景.安宫黄体酮联合妇康片治疗单纯型子宫内膜增生症对子宫内膜厚度及相关指标变化的影响[J].菏泽医学专科学校学报,2018,30(1):7~10.
[7] 孙小丽,赵春梅,曾俐琴,等.诺舒子宫内膜去除术治疗月经过多合并无不典型性子宫内膜增生患者的临床分析[J].现代妇产科进展,2019,28(6):460~462.
[8] 刘洋.非典型子宫内膜增生实施醋酸甲羟孕酮治疗的效果分析[J].基层医学论坛,2018,22(10):1437~1438.
[9] 邹宏兵,郑江红,胡玉峰,等.左炔诺孕酮宫内缓释系统治疗功能失调性子宫出血及子宫内膜增生过长临床疗效研究[J].中国性科学,2015,24(1):19~21.
[10] 卢天捷,马西焱.醋酸甲羟孕酮与达那唑治疗非典型子宫内膜增生症的临床效果[J].临床医学研究与实践,2018,3(17):77~78.
[11] 周敏,张呈艳,朱彩芳,等.左炔诺孕酮宫内缓释系统治疗子宫内膜增生的临床疗效及对患者性激素和性激素受体水平的影响[J].中国妇幼保健,2017,32(8):1771~1773.
[12] 王艳.左炔诺孕酮宫内缓释系统治疗子宫内膜增生的疗效及对性激素和性激素受体水平的影响[J].实用妇科内分泌电子杂志,2019,6(17):101~102. |
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2021, Vol. 27 
