磁共振定量参数对脑胶质瘤分级的诊断效能及与瘤组织EGFR Ki-67表达的关联性分析

doi:10.3969/j.issn.1006-6233.2021.06.033

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Abstract Objective: To explore the diagnostic efficacy of MRI quantitative parameters for the classification of glioma and its correlation with the expression of epidermal growth factor receptor (EGFR) and nuclear proliferation-related antigen (Ki-67) in tumor tissues. Methods: From January 2018 to April 2020, 87 patients with glioma admitted to our hospital were prospectively selected. According to the World Health Organization classification of tumors of the central nervous system, they were divided into low-grade group (grade Ⅱ, n=41) and high-grade group (grade Ⅲ, Ⅳ, n=46). The general data, quantitative parameters of magnetic resonance [volume transfer constant (K_trans), extravascular extracellular volume fraction (V_e), edema width] were compared between the two groups. The receiver operating characteristic curve (ROC) was used to evaluate the effectiveness of magnetic resonance quantitative parameters in the diagnosis of glioma grading, and the positive rates of EGFR and Ki-67 and the average integral optical density of the two groups were compared. Pearson was used to analyze the relationship between the quantitative parameters of magnetic resonance and the average integrated optical density of tumor tissue EGFR and Ki-67. Results: The K_trans, V_e and edema width of the high-grade group were higher than those of the low-grade group (P<0.05). The area under the curve (AUC) of MRI quantitative parameters K_trans, V_e, and edema width in the combined diagnosis of glioma classification was 0.891, which was greater than the single diagnosis of each parameter. The best sensitivity and specificity of combined diagnosis were 80.43% and 87.80%, respectively. The EGFR positive rate, Ki-67 positive rate and the average integrated optical density of EGFR and Ki-67 in the high-grade group were higher than those in the low-grade group (P<0.05). K_trans, V_e, and edema width were all positively correlated with the average integrated optical density of tumor tissue EGFR and Ki-67 (P<0.05). Conclusion: The quantitative parameters of magnetic resonance have good diagnostic performance in the grading diagnosis of glioma, and are positively correlated with the expression of EGFR and Ki-67 in tumor tissues. Early determination of the changes in the quantitative parameters of magnetic resonance can assist the clinical determination of the graded diagnosis of glioma and the expression of EGFR and Ki-67.

Key words： Glioma Quantitative parameters of magnetic resonance Grade Epidermal growth factor receptor Nuclear proliferation-associated antigen Diagnostic efficacy

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	CHEN Wen
	LI Zesheng
	ZHONG Kai

Cite this article:

CHEN Wen,LI Zesheng,ZHONG Kai. The Diagnostic Efficacy of MRI Quantitative Parameters in the Grading of Glioma and the Correlation Analysis with the Expression of EGFR and Ki-67 in Tumor Tissue[J]. HeBei Med, 2021, 27(6): 1035-1040.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.06.033 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I6/1035

[1] Kim YZ,Kim CY,Wee CW,et al.The korean society for neuro-oncology (KSNO) guideline for WHO grade II cerebral gliomas in adults:V_ersion 2019.01[J].Brain Tumor Res Treat,2019,7(2):74~84.
[2] Eskilsson E,Rosland GV,Solecki G,et al.EGFR heterogeneity and implications for therapeutic interV_ention in glioblastoma[J].Neuro Oncol,2018,20(6):743~752.
[3] 邓云秋.EGFR单克隆抗体靶向药物治疗脑胶质瘤的研究进展[J].中国处方药,2018,16(8):22~23.
[4] Gates EDH,Lin JS,Weinberg JS,et al.Guiding the first biopsy in glioma patients using estimated Ki-67 maps deriV_ed from MRI:conV_entional V_ersus advanced imaging[J].Neuro Oncol,2019,21(4):527~536.
[5] 中华医学会放射肿瘤治疗学分会.胶质瘤放疗中国专家共识(2017)[J].中华放射肿瘤学杂志,2018,27(2):123~131.
[6] 《中国中枢神经系统胶质瘤诊断和治疗指南》编写组.中国中枢神经系统胶质瘤诊断与治疗指南(2015)[J].中华医学杂志,2016,96(7):485~509.
[7] Liu Y,Li Y,He J,et al.Gender stratified analyses of the association of skinfold thickness with hypertension:a cross-sectional study in general northeastern chinese residents[J].Int Environ Res Public Health,2018,15(12):2748.
[8] 张祝辉.T1加权像动态对比增强MRI在脑胶质瘤微血管通透性及病理分级评价中的应用价值[J].医疗装备,2018,31(1):39~40.
[9] 李玉,李永,张建国,等.脑胶质瘤组织中趋化因子7的表达及其与病理、磁共振成像瘤周水肿的关系[J].中华实验外科杂志,2018,35(3):547~549.
[10] 王宁,印弘,康晓伟,等.DCE-MRI和3D-ASL定量参数在胶质瘤术前分级中的应用研究[J].实用放射学杂志,2019,35(5):699~703.
[11] Ciavattini A,Sopracordevole F,Di GJ,et al.Cervical intraepithelial neoplasia in pregnancy:Interference of pregnancy status with p16 and Ki-67 protein expression[J].Oncol Lett,2017,13(1):301~306.