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| Research on the Correlation Between Serum BNP γ-GT Levels and Neural Prognosis in Asphyxia Neonates |
| ZHANG Wei, YANG Ling, ZHONG Lihua |
| Hainan Women and Children's Medical Center, Hainan Haikou 570206, China |
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Abstract Objective: To study the correlation between serum brain natriuretic peptide (BNP), γ-glutamyl transpeptidase (γ-GT) levels and neural prognosis in asphyxia neonates. Methods: A total of 128 asphyxia neonates who were admitted to the hospital from February 2017 to June 2019 were enrolled, including 76 cases in mild group and 52 cases in severe group. Another 30 healthy neonates were enrolled as control group. The levels of serum BNP and γ-GT, and scores of neonatal behavioral neurological assessment (NBNA) were compared among the three groups. The efficiency of serum BNP and γ-GT levels for distinguishing mild asphyxia from severe asphyxia was analyzed by ROC curves. The correlation between expression level of BNP and γ-GT and NBNA score was analyzed by Pearson method. Results: There were significant differences in levels of BNP and γ-GT among the three groups (P<0.05). The levels of BNP and γ-GT were the highest in severe group, followed by mild groups and control group (P<0.05). The area under the curve (AUC) values for BNP and γ-GT to identify mild and severe asphyxia were 0.885 (95%CI: 0.827-0.943, P<0.001) and 0.847 (95%CI: 0.777-0.917, P<0.001), respectively. There were significant differences in NBNA scores of newborns with different degrees of asphyxia compared with control group (P<0.05).There were significant differences in NBNA scores among the three groups at different times, and the NBNA scores gradually increased, whose increase was more significant in severe group (P<0.05). The expression levels of BNP and γ-GT were negatively correlated with NBNA scores on the first day and 7th day in severe group [(r=-0.318, r=-0.352, P<0.05), (r=-0.303, r=-0.380, P<0.05)]. Conclusion: Serum BNP and γ-GT can effectively distinguish the severity of neonatal asphyxia. The expression levels of BNP and γ-GT on the first day and 7th day are correlated with neural prognosis in severe asphyxia neonates. The more severe the asphyxia, the higher the expression levels of BNP and γ-GT, and the lower the NBNA score.
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2021, Vol. 27 
