COPD患者血清sCD40L TNF-α及MMP-9水平及意义

doi:10.3969/j.issn.1006-6233.2021.05.010

Abstract
Figure/Table
References
Related Citation (9)

Download: PDF (1844 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To observe the expression levels of serum soluble CD40 ligand (sCD40L), tumor necrosis factor α (TNF-α) and matrix metalloproteinase 9 (MMP-9) in patients with chronic obstructive pulmonary disease (COPD) and analyze their significance. Methods: 82 patients with COPD were selected and divided into acute exacerbation group (n = 46) and clinical remission group (n = 36) according to the clinical staging. Meanwhile, 40 healthy people were made the control group. The expression levels of serum sCD40L, TNF-α and MMP-9 and lung function indexes [forced expiratory volume in 1s (FEV1), forced vital capacity (FVC), FEV1/FVC, the percentage of FEV1 in predicted value (FEV1%)] were compared among the 3 groups, and correlation analysis was performed. Results: The order of expression levels of serum sCD40L, TNF-α and MMP-9 in the 3 groups from high to low was as follows: the acute exacerbation group, the clinical remission group, the control group (P<0.017). The order of FEV1, FVC, FEV1/FVC and FEV1% in the 3 groups from low to high was as follows: the acute exacerbation group, the clinical remission group, the control group (P<0.017). Serum sCD40L, TNF-α and MMP-9 levels were negatively correlated with lung function (FEV1/FVC, FEV1%) in patients with COPD (P<0.05). Conclusion: The expression levels of serum sCD40L, TNF-α and MMP-9 in patients with COPD show an increasing trend, especially in patients with acute exacerbation. The higher the sCD40L, TNF-α and MMP-9 levels, the worse the lung function. The detection of the three indexes can provide an effective basis for the evaluation of COPD.

Key words： Chronic obstructive pulmonary disease Soluble CD40 ligand Tumor necrosis factor alpha Matrix metalloproteinase 9

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.05.010 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I5/746

[1] Ding Z,Wang K,Li J,et al.Association between glutathione S-transferase gene M1 and T1 polymorphisms and chronic obstructive pulmonary disease risk: a meta-analysis[J].Clin Genet,2019,95(1):53~62.
[2] Huan W,Tianzhu Z,Yu L,et al.Effects of ergosterol on COPD in mice via JAK3/STAT3/NF-κB pathway[J].Inflammation,2017,40(3):884~893.
[3] Murphy TF,Kirkham C,Gallo MC,et al.IgA protease variants facilitate intracellular survival in epithelial cells by nontypeable haemophilus influenzae that persist in the human respiratory tract in COPD[J].Infect Dis,2017,216(10):1295~1302.
[4] De J Guerrero-Garcia J,Rojas-Mayorquin AE,Valle Y,et al.Decreased serum levels of sCD40L and IL-31 correlate in treated patients with Relapsing-Remitting Multiple Sclerosis[J].Immunobiology,2018,223(1):135~141.
[5] 王晓娟,方向阳.慢性阻塞性肺疾病全球倡议2019:慢性阻塞性肺疾病诊断、治疗与预防全球策略解读[J].中国全科医学,2019,22(18):2141~2149.
[6] 陈志远,张忆,吴健华,等.多索茶碱对机械通气诱发COPD大鼠肺炎症反应的影响[J].中华麻醉学杂志,2019,39(1):28~30.
[7] 赵春柳,黄靓雯,张利,等.慢性阻塞性肺疾病急性加重住院患者呼吸道病毒感染与炎症细胞因子的相关性[J].中华结核和呼吸杂志,2018,41(12):942~948.
[8] 孙剑峰,郭鸿,曾珠,等.三拗芎葶汤对COPD急性加重期(痰热壅肺证)肺功能和TNF-α影响的临床研究[J].中药药理与临床,2018,34(4):169~172.
[9] FanJX,Li ZH,Liu XH,et al.Bacteria-mediated tumor therapy utilizing photothermally-controlled TNF-α expression via oral administration[J].Nano Lett,2018,18(4):2373~2380.
[10] 武红莉,田瑞雪,宁兰丁,等.慢性阻塞性肺疾病患者肺部感染的影响因素分析及血清炎症因子水平变化分析[J].中华医院感染学杂志,2018,28(1):25~28.
[11] 方利文,王临虹.中国居民慢性阻塞性肺疾病监测意义重大[J].中华流行病学杂志,2018,39(5):541~545.
[12] 王晓玲,黄钟,邓广雪,等.TXNIP/NLRP3炎性小体通路在COPD患者机体炎症反应中的作用研究[J].中国免疫学杂志,2019,35(6):729~734.
[13] 潘娜,陈乾华,辛丽云,等.痰上清液MMP-9、TIMP-1与慢性阻塞性肺疾病气道炎症的关系[J].中国老年学杂志,2017,37(9):2221~2223.
[14] 张铷涓,程安春,汪铭书.CD40/CD40L在抗病毒免疫应答过程中的作用[J].细胞与分子免疫学杂志,2018,34(1):94~98.
[15] Senchenkova EY,Janice R,Vital SA,et al.A critical role for both CD40 and VLA5 in angiotensin Ⅱ–mediated thrombosis and inflammation[J].Faseb,2018,32(6):3448~3456.