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| Effects of Sevoflurane Combined with Propofol Inhalation Duration on Postoperative Cognitive Function in Patients Undergoing Radical Mastectomy |
| CUI Dezhuang, FANG Liang, FENG Chunlin |
| The First Hospital of Zibo City, Shandong Zibo 255200, China |
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Abstract Objective: To observe the effect of sevoflurane combined with propofol inhalation duration on postoperative cognitive function in patients with radical mastectomy.Methods: 104 cases of breast cancer patients who underwent surgery in our hospital from August 2016 to August 2019 were selected and randomly divided into observation group and control group, 52 cases in each group. Both groups were given low-flow inhaled sevoflurane and pump propofol for anesthesia maintenance, while continuous intravenous infusion of remifentanil for analgesia.In the control group, sevoflurane was stopped after inhalation for 2h and only pumped propofol was used for anesthesia maintenance. In both groups, all anesthetic drugs were stopped at the time of surgical suture and oxygen supply was given. Observed two groups of patients with connecting electrical double frequency index (BIS) monitor (T0), 3 min after anesthesia induction (T1), 1 min after intubation (T2), cut skin (T3), sewing leather after 1 min after 1 min (T4) BIS index, compared two groups of patients with postoperative spontaneous breathing recovery time, open time, extubation time and language can be stated time, compared two groups of patients before and after 1~12h operation, Montreal cognitive scale (MoCA) score, compared two groups of patients with postoperative hypotension, vomiting, bronchospasm, incidence of adverse reactions such as tachycardia. Results: There was no significant difference in body mass index (BMI), male proportion and man proportion between the two groups, all with P>0.05. The BIS index of two groups of patients changed with time, and the role of time factors varied with different groups, P<0.05; the BIS index at each time pant (T1, T2, T3, T4) in the two groups were significantly decreased, P<0.05; At the same time,there was no significantly difference in T0, T1, T2, T3 between the two groups (P>0.05). The BISindex at T4 in the observation group was significantly higher than that in the control group (P<0.05). The recovery time of spontaneous breathing, eye opening time, extubation time and verbal statement time in the observation group were significantly shorter than those in the control group, P<0.05. MOCA scores of the two groups were changed with time, and the effect of time factor was different with different groups, P<0.05; at the same time, MOCA scores of the observation group at 1h, 6h, 12h after operation were significantly higher than those of the control group, all P<0.05. The total incidence of postoperative adverse reactions in the observation group was not significantly different from that in the control group, P>0.05. Conclusion: The inhalation of sevoflurane for anesthesia during the whole course of radical mastectomy for breast cancer has little impact on the cognitive function of breast cancer patients, and the recovery time of inhalation anesthesia during the whole course is fast, without increasing adverse reactions, which is worthy of clinical promotion.
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2021, Vol. 27 
