富马酸替诺福韦联合扶正化瘀治疗对乙肝肝硬化患者肝纤维化程度及免疫状态的影响

doi:10.3969/j.issn.1006-6233.2021.04.034

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Abstract Objective: To observe the effects of tenofovir disoproxil fumarate combined with Fuzheng Huayu on liver fibrosis degree and immune status of patients with hepatitis B cirrhosis.Methods: A total of 150 patients with hepatitis B cirrhosis who were treated in our hospital from January 2018 to June 2019 were selected as subjects, and they were divided into observation group and control group according to the simple random grouping, with 75 cases in each group. Control group was treated with tenofovir disoproxil fumarate, and observation group was combined with Fuzheng Huayu on the basis of control group, and the two groups took 24 weeks as a course of treatment. The liver function [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), albumin (ALB)], liver fibrosis indicators [hyaluronic acid (HA), laminin (LN), type III procollagen (PC III), type IV collagen (IV-C)], virological indicators [negative conversion rate of hepatitis B virus gene (HBV DNA negative conversion rate), negative conversion rate of hepatitis B virus e antigen (HbeAg negative conversion rate)], imaging indicators (portal vein diameter, portal vein blood flow velocity, spleen thickness, spleen length, portal blood flow) and immune function (CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺) were compared between the two groups before treatment and after 24 weeks of treatment, and the occurrence of adverse reactions during treatment were recorded in the two groups. Results: Before treatment, there were no statistically significant differences in the ALT, AST, TBIL, ALB, HA, LN, PC III, IV-C, portal vein diameter, portal vein blood flow velocity, spleen thickness, spleen length, portal blood flow, CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺ between the two groups (all P>0.05). After 24 weeks of treatment, the ALT, AST, TBIL, HA, LN, PC III, IV-C, portal blood flow and CD8+ in the two groups were significantly lower than those before treatment (all P<0.05) while the ALB, portal vein blood flow velocity, CD3⁺, CD4⁺ and CD4⁺/CD8⁺ were significantly higher than those before treatment (all P<0.05). There were no statistically significant differences in the differences of ALT, AST, TBIL and ALB before and after treatment between the two groups (all P>0.05), and the differences of HA, LN, PC III, IV-C, portal vein blood flow velocity, portal blood flow, CD3⁺, CD4⁺, CD4⁺/CD8⁺ and CD8⁺ before and after treatment in observation group were significantly higher than those in control group (P<0.05). After 24 weeks of treatment, there were no statistically significant differences in the HBV DNA negative conversion rate and HbeAg negative conversion rate between the two groups (P>0.05). The total incidence rate of adverse reactions was 6.67% in observation group and was 4.00% in.control group (χ²=0.528, P=0.467). Conclusion: Tenofovir disoproxil fumarate combined with Fuzheng Huayu can indeed effectively improve the liver function, alleviate the liver fibrosis degree, accelerate portal vein blood flow and help improve the immune function, and it is safe and reliable, and is beneficial to the disease outcomes.

Key words： Hepatitis B cirrhosis Tenofovir disoproxil fumarate Fuzheng huayu Iiver fibrosis Immune status Liver function

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	HU Huifen
	LIU Wen
	TAN Lin

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HU Huifen,LIU Wen,TAN Lin. Effects of Tenofovir Disoproxil Fumarate Combined with Fuzheng Huayu on Liver Fibrosis Degree and Immune Status of Patients with Hepatitis B Cirrhosis[J]. HeBei Med, 2021, 27(4): 686-692.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.04.034 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I4/686

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