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An Analysis of Risk Factors Related to the Depth of Invasion in Esophageal Carcinoma |
DING Dandan, ZHOU Yingfa, HUANG Linkai |
The Second Affiliated Hospital of Zhengzhou University, Henan Zhengzhou 450014, China |
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Abstract Objective: To study the related risk factors inherent in the invasive depth of esophageal cancer,and provide a more accurate method to judge the invasive depth of esophageal cancer. Methods: A total of 174 patients (174 lesions) diagnosed with esophageal cancer via gastroscopy and pathological diagnosis in the Second Affiliated Hospital of Zhengzhou University from June 2014 to June 2020,including 102 males (58.6%),72 females (41.4%),were retrospectively analyzed. The age,gender,tumor location,tumor size,preoperative PLR,NLR,LMR and postoperative pathological diagnosis were observed and recorded. Results: High PLR was significantly correlated with the depth of invasion (> SM1 vs ≤SM1:OR=1.017,95% CI=1.006 ~ 1.028,P = 0.002); tumor length was significantly correlated with the depth of invasion (> SM1 vs ≤SM1:OR=1.581,95% CI=1.234 ~ 2.024,P<0.001),where AUC was 0.74 and 0.796. The sensitivity was 0.495 and 0.722,and the specificity respectively was 0.883 and 0.714. The AUC,sensitivity and specificity of PLR combined with tumor length was 0.812,0.866 and 0.61. Conclusion: PLR and tumor length are accurate in their diagnostic capabilities for the depth of the invasion of esophageal cancer,and their combination can further improve accuracy and provide a more reliable basis for treatment options.
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