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| Efficacy of Hydroxychloroquine Sulfate on Sjogren's Syndrome and Its Effects on Levels of Serum IL-17 ESR CRP and IgG |
| FENG Lin, XU Yangyang, LI Mingyao |
| Deyang People' s Hospital, Sichuan Deyang 618000, China |
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Abstract Objective: To study the efficacy of hydroxychloroquine sulfate in the treatment of Sjogren’s syndrome (SS) and the effects on levels of serum interleukin-17 (IL-17), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and immunoglobulin G (IgG). Methods: A total of 194 SS patients admitted to our hospital from March 2017 to March 2020 were randomly and evenly divided into observation group and control group, with 97 cases in each group. Both groups were given methylprednisolone on the basis of symptomatic treatment, and observation group was additionally given hydroxychloroquine sulfate during treatment, and the treatment lasted 3 months. The treatment effects and adverse reactions were observed in the two groups, and the Schirmer Test (ST), salivary flow rate (SFR) and levels of serum IL-17, ESR, CRP and IgG were detected before and after treatment. Results: The treatment effects in observation group were significantly better than those in control group (P<0.05), and the effective rates of the two groups were 86.60% and 75.26% (P<0.05). There were no significant differences in ST and SFR between the two groups before treatment (P>0.05). After treatment, ST and SFR were significantly increased (P<0.05), and the differences of ST and SFR in observation group after treatment were higher than those in control group (P<0.05). There were no significant differences in the levels of serum IL-17, ESR, CRP and IgG between the two groups before treatment (P>0.05). After treatment, the levels of serum IL-17, ESR, CRP and IgG were significantly reduced (P<0.05), and the differences of IL-17, ESR, CRP and IgG before and after treatment in observation group were higher than those in control group (P<0.05). The incidence rates of adverse reactions in observation group and control group were 16.49% and 12.37% respectively (P>0.05). Conclusion: Hydroxychloroquine sulfate in the adjuvant treatment of SS can effectively reduce the levels of serum IL-17, ESR, CRP and IgG, thereby improving the symptoms and enhancing the treatment effects.
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2021, Vol. 27 
