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| Effects of Paroxetine and Olanzapine Respectively Combined with Flupentixol-Melitracen on HAMD, BI and NIHSS Scores in Patients with Post-Stroke Depression |
| MA Han, WANG Hui, WANG Meng |
| Suzhou Hospital of Anhui Medical University / Suzhou Municipal Hospital, Anhui Suzhou 234000, China |
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Abstract Objective: To investigate the effect of paroxetine and olanzapine respectively combined with flupentixol-melitracen on the quality of life of post-stroke depression patients. Methods: From February 2017 to April 2019, 126 patients with stroke depression in our hospital were randomly divided into 3 groups by random number table method, 42 cases each in paroxetine combination group, olanzapine combination group and control group. Paroxetine combination group received paroxetine combined with flupentixol-melitracen, olanzapine combination group received olanzapine combined with flupentixol-melitracen, and the control group received flupentixol-melitracen alone treatment. The course of treatment is 8 weeks. The treatment efficacy, NIHSS, HAMD, BI score, and adverse reactions of the three groups were compared. Results: The therapeutic effect of the paroxetine combination group and olanzapine combination group was better than that of the control group (Z=3.063, 2.301, P<0.05); The total effective rates of the paroxetine combination group and olanzapine combination group were 95.24% and 90.48%, significantly higher than 73.81% of the control group (P<0.0167). After treatment, the NIHSS and HAMD scores of the three groups were significantly decreased (P<0.05), and the BI score was significantly increased (P<0.05); NIHSS and HAMD of the paroxetine combineation group and olanzapine combination group were significantly lower than that of the control group (P<0.05), the BI score was significantly higher than the control group (P<0.05). The incidences of total adverse reactions in the paroxetine combination group, olanzapine combination group and control group after treatment were 66.67%, 80.95% and 78.57% respectively. There was no statistically significant difference in the incidence of total adverse reactions among the three groups (P>0.05 ). Conclusion: Paroxetine combined with flupentixol-melitracen and olanzapine combined with flupentixol-melitracen in stroke patients with depression has a significant therapeutic effect compared with the use of flupentixol-melitracen alone. It can effectively reduce the degree of neurological deficit and depression, improve the ability of life, and will not increase adverse reactions.
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2021, Vol. 27 
