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Predictive Value of Fractional Flow Reserve Combined with Serum ESM-1 Level for Cardiovascular Events and In-Stent Restenosisin Patients with AMI After PCI |
HUANG Qi, CUI Yan, FU Yingjie |
Shanghai Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200086, China |
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Abstract Objective: To explore predictive value of fractional flow reserve (FFR) combined with serum endothelial cell specific molecule 1 (ESM-1) level for cardiovascular events (CE) and in-stent restenosis (ISR) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods: The influencing factors of CE and ISR in the 182 AMI patients after PCI, and the predictive value of FFR combined with ESM-1 for CE and ISR were retrospectively analyzed. Results: ESM-1 in CE group and ISR group was higher than that in non-cardiovascular event (NCE) group and non-ISR (NISR) group, while FFR was lower than that in NCE group and NISR group, respectively (P<0.05). AUC values of FFR combined with ESM-1 for predicting CE and ISR were 0.874 and 0.884, which were higher than those of single index (P<0.05). ESM-1 was an independent risk factor of CE, and FFR was an independent protective factor of ISR within 1 year after PCI in AMI patients (P<0.05). Conclusion: ESM-1 was an independent risk factor of CE and ISR within 1 year after PCI in AMI patients, while FFR was an independent protective factor. The predictive value of their combination detection for CE and ISR is relatively higher.
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