老年冠心病慢性心衰患者血清miR-214 galectin-3表达及其预后相关性研究

doi:10.3969/j.issn.1006-6233.2021.01.011

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Abstract Objective: To detect the levels of serum microRNA-214 (miR-214) and galectin-3 in elderly patients with coronary heart disease and chronic heart failure, and to explore the correlation between their levels and prognosis. Methods: From July 2017 to April 2019, 72 elderly patients with chronic heart failure of coronary heart disease in the Department of Cardiology of our hospital were selected as heart failure group; at the same time, 84 healthy people were selected as the control group; in addition, according to whether cardiovascular events occurred within 12 months after discharge, patients with chronic heart failure were divided into cardiovascular event group (23 cases) and non cardiovascular event group (49 cases). The level of serum miR-214 was detected by real-time fluorescent quantitative PCR (qRT-PCR); the levels of serum galectin-3 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were detected by enzyme linked immunosorbent assay (ELISA); left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter (LVESD) were measured by echocardiography; the correlation between serum miR-214, galectin-3 and cardiac function indexes in patients with chronic heart failure was analyzed; and the factors influencing the prognosis of patients with chronic heart failure were analyzed. Results: MiR-214, galectin-3, LVESD, LVEDD and NT-proBNP in HF group were higher than those in the control group, and LVEF was lower than that in the control group (P<0.05); the levels of serum miR-214 and galectin-3 were positively correlated with LVESD, LVEDD and NT-proBNP (P<0.05), and negatively correlated with LVEF (P<0.05); miR-214, galectin-3, LVESD, LVEDD and NT-proBNP in cardiovascular event group were higher than those in non cardiovascular event group, and LVEF was lower than those in non cardiovascular event group (P<0.05); miR-214 and galectin-3 were independent risk factors of adverse cardiovascular events in patients with chronic heart failure (P<0.05), and LVEF was the protective factor of adverse cardiovascular events in patients with chronic heart failure (P<0.05). Conclusion: The levels of serum miR-214 and galectin-3 may play an important role in predicting the prognosis of elderly patients with chronic heart failure of coronary heart disease.

Key words： Chronic heart failure of coronary heart disease Elderly Serum MicroRNA-214 Galectin-3 Prognosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.01.011 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I1/45

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