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| Effect of Propofol Combined with Remifentanil or Sufentanil on the Dosage and Cognitive Level of Propofol in Resection of Cerebral Cortex Tumor |
| HE Yi, DENG Guokui, WU Caihong |
| Hefei Tumor Hospital of Chinese Academy of Sciences, Anhui Hefei 230000, China |
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Abstract Objective: To investigate the effect of propofol combined with remifentanil or sufentanil on propofol dosage and cognitive level in remifentanil. Methods: From January 2016 to November 2019, 70 patients with cerebral cortical functional area tumors underwent craniotomy in our hospital were randomly divided into 35 cases of remifentanil group (group RF) and sufentanil group (group SF). Group RF was anesthetized intravenously with propofol combined with remifentanil. Group SF was anesthetized intravenously with propofol combined with sufentanil. The pre-induction (T0), during intubation (T1), 1 min after intubation (T2), 5 min after intubation (T3), After extubation (T4) propofol plasma target concentration, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were observed and compared between the two groups. The cognitive changes of the two groups were observed and compared. Results: Compared with the target concentration of propofol at different time points in the two groups, group RF was significantly lower than group SF (P<0.05). After extubation, the plasma concentration of propofol in group RF was lower than that in group SF (P<0.05). The MMSE scores in group RF were higher than those in group SF (P<0.05) after 5 days after operation (P>0.05). The adverse reaction rate of group RF (17.14%) was significantly lower than that of SF group (40%) (P<0.05). Conclusion: Compared with propofol combined with sufentanil, propofol combined with remifentanil can reduce the plasma target concentration of propofol in anesthesia, reduce the dosage of propofol appropriately, and effectively reduce the degree of cognitive impairment after operation.
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2020, Vol. 26 
