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Analysis of Treatment Effect and Cost of Imipenem Cilastatin Sodium and Meropenem in Patients with Severe Pulmonary Infection |
XIONG Guo, WU Xiuqin, HUANG Qiongxiu, et al |
Zhujiang Hospital, Southern Medical University, Guangdong Guangzhou 510000, China |
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Abstract Objective: To analyze the clinical symptoms of patients with severe pulmonary infection, and to give imipenem cilastatin sodium and meropenem treatment according to the actual situation of the case, explore the final effect of the program and calculate the treatment cost. Methods: 80 patients with severe pulmonary infection admitted to our hospital from January 2017 to December 2019 were selected as the study subjects. They were divided into two groups by the red-and-blue grouping method. Patients in group A were treated with imipenem xastatin sodium, and patients in group B were treated with meropenem. The intervention effect, blood gas level, inflammatory index, bacteria culture result, drug susceptibility test result and treatment cost were compared. Results: There was no significant difference in intervention effect between group A and group B (80.0%VS85.0%) (P>, 0.05). Before intervention, there was no significant difference in blood gas index and inflammatory index between the two groups (P>0.05). After intervention, the blood gas levels of group A, PaO2, PCO2, PaO2/FiO2, PCT and CRP were all better than those of group B, with statistically significant difference (P<0.05). After treatment, the bacteria culture of group B was lower than that of group A (P<0.05). The cost-effectiveness of treatment in group B was significantly lower than that in group A (P<0.05). Conclusion: Both imipenem and cilastatin sodium and meropenem are of positive significance in the treatment of severe pulmonary infection. Meropenem is better than imipenem and cilastatin sodium in improving patients' blood gas level, immunity, and pathogen removal, reducing the treatment effect-cost, and its clinical application value is better than imipenem cilastatin sodium.
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