Treg/Th17细胞失衡及相关细胞因子表达水平与再生障碍性贫血的关系分析

doi:10.3969/j.issn.1006-6233.2020.10.036

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Abstract Objective: To explore the relevance between Treg/Th17 cell imbalance, expression levels of related cytokines and aplastic anemia (AA). Methods: 94 AA patients who were admitted to the cooperative hospital from December 2016 to June 2018 were enrolled. According to disease severity, they were categorized into mild AA (MAA) group (41 cases) and severe AA (severe AA) group (53 cases). 50 healthy people who underwent physical examination in the hospital during the same period were enrolled as control group. The levels of Treg and Th17 in peripheral blood were detected by flow cytometry. The levels of serum IL-10, IL-6 and IL-17 were detected by enzyme-linked immunosorbent assay (ELISA). The relevance between Treg/Th17 cell imbalance, related cytokines and AA severity, prognosis was analyzed. Results: Treg cell level and Treg/Th17 in SAA group were lower than those in control group and MAA group, while Th17 level was higher than that in control group and MAA group (P<0.05). The level of IL-10 in SAA group was lower than that in control group and MAA group, while levels of IL-6 and IL-17 were higher than those in control group and MAA group (P<0.05). The levels of Treg, Treg/Th17 and IL-10 were negatively correlated with disease severity (r1=-0.604, r2=-0.661, r3=-0.611, P<0.05). Th17, IL-6 and IL-17 were positively correlated with disease severity (r1=0.475, r2=0.486, r3=0.535, P<0.05). After multivariate Logitic regression model analysis, Treg and Treg/Th17 were protective factors influencing disease prognosis (acute recurrence or death) (P<0.05). Conclusion: There is an imbalance of Treg/Th17 cells and related cytokines in AA patients. The imbalance of Treg/Th17 cells is closely related to the severity and prognosis of AA.

Key words： Treg/Th17 Cytokine Aplastic anemia Prognosis Correlation

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	WANG Rui
	DONG Caili
	ZHAO Yunting
	et al

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WANG Rui,DONG Caili,ZHAO Yunting, et al. An Analysis of the Relevance Between Treg/Th17 Cell Imbalance, Expression Levels of Related Cytokines and Aplastic Anemia[J]. HeBei Med, 2020, 26(10): 1738-1742.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.10.036 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I10/1738

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