lncRNA CCHE1与肺腺癌临床特征及预后的关系研究

doi:10.3969/j.issn.1006-6233.2020.10.031

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1394 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To explore the relevance between long non-coding RNA (lnc RNA) CCHE1 expression and clinical features, prognosis of lung adenocarcinoma. Methods: Eighty-three patients with lung adenocarcinoma who underwent surgical resection from December 2015 to December 2016 were enrolled. The paraffin blocks of lung cancer tissues and adjacent normal tissues were collected. The expression of lnc RNA CCHE1 was detected by qRT-PCR. The relevance between its expression and clinicopathological features of patients were analyzed. The prognosis of patients was followed up. The value of lnc RNA CCHE1 expression in prognosis determining was analyzed. Results: The expression of lnc RNA CCHE1 in lung adenocarcinoma tissues was significantly higher than that in adjacent tissues (P<0.05). The expression of lnc RNA CCHE1 in patients with high TNM stage, lymph node metastasis and poor differentiation degree was significantly higher than that with low TNM stage, without lymph node metastasis and with high differentiation degree (P<0.05). AUC of lnc RNA CCHE1 for diagnosis of lung adenocarcinoma was 0.925 (95%CI: 0.876-0.974). When lnc RNA CCHE1 was not lower than 29.18, the sensitivity and specificity were 94.0% and 89.2%, respectively. 22 patients died and 61 survived. The expression of lnc RNA CCHE1 in the dead was (73.15 ± 8.45), which was significantly higher than that in the survivors(P<0.05). The 3-year progression-free survival (PFS) rate and overall survival rate in patients with high expression of lnc RNA CCHE1 were 32.84% (22/67) and 68.66% (46/67), which were significantly lower than those with low expression (P<0.05). TNM stage, lymph node metastasis, differentiation degree and lnc RNA CCHE1 level were independent factors affecting PFS and OS in patients with lung adenocarcinoma after 3 years of surgery (P<0.05). Conclusion: The expression of lnc RNA CCHE1 is increased in lung adenocarcinoma tissues. Its expression is relevant to clinicopathological features and prognosis of patients, which can be applied as a potential molecular marker of lung adenocarcinoma.

Key words： Lnc RNA CCHE1 Lung adenocarcinoma Clinical feature Prognosis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	TANG Rongbin
	WANG Gang

Cite this article:

TANG Rongbin,WANG Gang. A Study of the Relevance Between lncRNA CCHE1 and Clinical Features Prognosis of Lung Adenocarcinoma[J]. HeBei Med, 2020, 26(10): 1715-1720.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.10.031 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I10/1715

[1] 孙可欣,郑荣寿,曾红梅,等.2014年中国肺癌发病和死亡分析[J].中华肿瘤杂志,2018,40(11):805~811.
[2] SoriaJC,OheY,VansteenkisteJ,et al.Osimertinib in untreated EGFR-mutated advanced non-small-cell lung cancer[J].N Engl Med,2018,378(2):113~125.
[3] Chen W,ZhuH,YinL,et al.lncRNA-PVT1 facilitates invasion through upregulation of MMP9 in nonsmall cell lung cancer cell[J].DNA Cell Biol,2017,36(9):787~793.
[4] Yang M,ZhaiX,XiaB,etal.Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregulating PCNA[J].Tumor Biol,2015,36(10):7615~7622.
[5] 杨小林. 非小细胞肺癌患者埃兹蛋白、血管抑制蛋白1的表达与微血管密度的相关性研究[J].标记免疫分析与临床,2019,26(2):259~263.
[6] Seiler J,BreinigM,Caudron-Herger M,etal.Thelnc RNA VELUCT strongly regulates viability of lung cancer cells despite its extremely low abundance[J].Nucleic Acids Res,2017,45(9):5458~5469.
[7] PengW,FanH.Long noncoding RNA CCHE1 indicates a poor prognosis of hepatocellular carcinoma and promotes carcinogenesis via activation of the ERK/MAPK pathway[J].Biomed Pharmacother,2016,83:450~455.
[8] Yu Y, Qian L, Cui J. Value of neutrophiltolymphocyte ratio for predicting lung cancer prognosis: a metaanalysis of 7,219 patients[J]. Mol Clin Oncol, 2017, 7(3):498~506.
[9] 单文莉,周围,孔丹,等.肺腺癌CT征象与病理组织学亚型及分化程度的对照研究[J].临床放射学杂志,2019,38(12):2312~2316.
[10] Wang X,LiG,LuoQ,etal.Integrated TCGA analysis implicates lncRNA CTB-193M12.5 as a prognostic factor in lung adenocarcinoma[J].Cancer Cell Int,2018,18(1):27~42.
[11] Tuomas Tammela, Francisco Javier Sanchez-Rivera, Naniye Malli Cetinbas,et al. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma[J]. Nature, 2017, 545(7654):355~359.
[12] XuG,ZhangY,LiN,etal.Lnc RNA CCHE1 in proliferation and apoptosis of gastric cancer cells[J].Eur Rev Med Pharmacol Sci,2018,22(9):2631~2637.
[13] 陈晓,魏立,李基伟,等.异源肺癌细胞微小RNA-21差异性表达促进肺癌转移[J].中华实验外科杂志,2019,36(7):1229~1231.