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| The Study of the Effects of Medication Time and Dose of Oxytocin on the Severity of Neonatal Jaundice |
| ZHU Tong'e, ZHANG Jingjing, LI Xiumin |
| Qingdao Jiaozhou Central Hospital, Shandong Qingdao 266300, China |
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Abstract Objective: To analyze the effect of medication time and dose of oxytocin on the severity of neonatal jaundice. Methods: A total of 1,320 pregnant women who underwent vaginal delivery in Jiaozhou Central Hospital from September 2019 to April 2020 were enrolled. Among them, 570 cases treated with oxytocin before delivery were included in experimental group and 750 oxytocin-free cases were included in control group. The changes of maternal umbilical cord serum total bile acid (TBA) after delivery, and neonatal transcutaneous bilirubin within 4d after birth were compared between the two groups. The incidences of neonatal jaundice in both groups were recorded. Meanwhile, the incidences of neonatal jaundice and transcutaneous bilirubin levels were compared among subgroups of the experimental group (pregnant women in the experimental group were divided into oxytocin use 1 ~ 2 h group, 3 ~ 4 h group and 4 ~ 5 h group according to the medication time of oxytocin, and they were divided into 5 ~ 10U group, 11 ~ 16U group and > 16U group according to the dose of oxytocin used) . Results: The maternal umbilical cord blood TBA levels in experimental group were significantly higher than those in the control group after delivery (P<0.05). On the 1st, 2nd, 3rd and 4th day after birth, neonatal percutaneous bilirubin levels in experimental group were higher than those in control group (P<0.05). The incidences of neonatal pathological jaundice and physiological jaundice and total incidence of jaundice in experimental group were higher than those in control group (P<0.05). In experimental group, the incidences of jaundice and percutaneous bilirubin within 4d after birth in neonates born by puerperae in 3 ~ 4 h group were lower than those born by 1 ~ 2 h group and 4 ~ 5 h group (P<0.05). The incidences of jaundice in neonates born by puerperae in 5 ~ 10 U group and 11 ~ 16 U group were lower than those born by > 16 U group (P<0.05). On the 2nd, 3rd and 4th day after birth, percutaneous bilirubin in neonates born by puerperae in 11 ~ 16 U group and > 16 U group was higher than 5 ~ 10 U group (P<0.05). Conclusion: Prenatal application of oxytocin may increase the risk of neonatal jaundice, and the incidence of neonatal jaundice is relatively higher in puerperae with oxytocin dose higher than 16U. Besides, the effect of oxytocin medication time of 3 ~ 4 h and dose of 11 ~ 16 U is the least.
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2020, Vol. 26 
