lncRNA SNHG20表达与乳腺癌放疗敏感性及预后的关系

doi:10.3969/j.issn.1006-6233.2020.10.015

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Abstract Objective: To detect the expression of lncRNA SNHG20 in breast cancer and normal breast tissue, and to analyze its relationships with radiosensitivity and prognosis of breast cancer. Methods: 119 patients with breast cancer admitted to our hospital from November 2013 to October 2016 were selected as the research objects, with their biopsy cancer tissue being collected, and 119 normal breast tissues retained in our hospital pathological database during the same period were selected as the control group. Real-time fluorescence quantitative (qRT-PCR) was used to detect the expression of lncRNA SNHG20, and then its association with clinicopathological characteristics and radiosensitivity of breast cancer patients were analyzed. Cox regression model was used to analyze the independent risk factors for prognosis of breast cancer patients. Results: The expression level of lncRNA SNHG20 in breast cancer tissue was significantly higher than that in normal breast tissue (P<0.05). The expression of lncRNA SNHG20 in breast cancer tissues was correlated with differentiation, TNM stage, lymph node metastasis and adjuvant chemotherapy (all P<0.05). The remission rate of patients with high expression of lncRNA SNHG20 after radiotherapy was significantly lower than that of patients with low expression of lncRNA SNHG20 (P<0.05). The 3-year overall survival rate of patients with high expression of lncRNA SNHG20 was significantly lower than that of patients with low expression of lncRNA SNHG20 (P<0.05). TNM stage III, lymph node metastasis and high expression of lncRNA SNHG20 were independent risk factors for poor prognosis of breast cancer patients (all P<0.05). Conclusion: LncRNA SNHG20 is highly expressed in breast cancer, and is related to low radiosensitivity, TNM stage, lymph node metastasis and overall survival rate of breast cancer patients. It may be a marker of radiosensitivity and prognosis of breast cancer, and provide a theoretical basis for improving the clinical efficacy and prognosis of breast cancer patients.

Key words： lncRNA SNHG20 Breast cancer Radiosensitivity

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	WEN Lanxiang
	QIN Shiyun
	CHEN Lijun

Cite this article:

WEN Lanxiang,QIN Shiyun,CHEN Lijun. The Association Between the Expression of lncRNA SNHG20 and Radiosensitivity Prognosis of Breast Cancer[J]. HeBei Med, 2020, 26(10): 1647-1651.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.10.015 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I10/1647

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