食管鳞癌根治术患者组织中CD8<sup>+</sup>/FOXP3<sup>+</sup>比值及PD-L1表达与预后的相关性

doi:10.3969/j.issn.1006-6233.2020.09.09

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1326 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To explore the correlation between CD8⁺/FOXP3⁺, expression of programmed death ligand 1 (PD-L1) in tissues and prognosis of patients undergoing radical operation of esophageal squamous carcinoma (ESCC).Methods: During the period from January 2014 to January 2019, 110 archived wax specimens and 110 wax specimens of normal tissues adjacent to the cancer (longer than 5 cm away from lesion, confirmed as cancer-free infiltration) from patients who underwent radical operation of ESCC in the hospital were enrolled as study objects.The expression of CD8⁺, FOXP3⁺ and PD-L1 in ESCC tissues was detected by immunohistochemistry, and the relationship between pathological parameters and prognosis was analyzed.Results: The positive expression rate of CD8⁺/FOXP3⁺ in ESCC tissues was lower than that in adjacent tissues, while the positive expression rate of PD-L1 was higher than adjacent tissues (P<0.05).Univariate and multivariate analysis showed that TNM stage T3, lymph node metastasis, positive expression of PD-L1 and negative expression of CD8⁺/FOXP3⁺ were independent risk factors affecting prognosis of ESCC patients (P<0.05).Conclusion: Positive expression of CD8⁺/FOXP3⁺, negative expression of PD-L1, TNM stage T3 and lymph node metastasis are independent risk factors affecting prognosis of patients after radical operation of ESCC.

Key words： Esophageal squamous carcinoma Radical operation CD8⁺/FOXP3⁺ PD-L1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Chengwei
	CHANG Kuan
	MAO Zhigang
	et al

Cite this article:

ZHANG Chengwei,CHANG Kuan,MAO Zhigang, et al. The Correlation Between CD8⁺/FOXP3⁺ Ratio PD-L1 Expression in Tissues and Prognosis in Patients Undergoing Radical Operation of Esophageal Squamous Carcinoma[J]. HeBei Med, 2020, 26(9): 1441-1445.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.09.09 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I9/1441

[1] Li R , Ke S , Meng F , et al. CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13[J]. Cell Death & Disease, 2018, 9(8):838.
[2] Liu B,Pan C F,Yao G L,et al.The long non-coding RNA AK001796 contributes to tumor growth via regulating expression of p53 in esophageal squamous cell carcinoma[J].Cancer Cell International,2018,18(1):38~59.
[3] Li D , Jin F , Ni T , et al. Mechanism of Jinlong capsule (JLC) in human esophageal squamous cell carcinoma (ESCC) via the MAPK signal pathway[J]. International Journal of Pharmacology, 2019, 15(1):74~83.
[4] Zhou H , Liu Y , Zhu R , et al. OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability[J]. Oncogene, 2018, 37(25 ):3356~3368.
[5] 董海峰,郑英斌,庞志刚,等.E-钙黏蛋白与波形蛋白在胃癌中的表达及意义[J].中华实用诊断与治疗杂志,2018,32(6):580~582.
[6] 薛亚斌,吕红博,瓦热斯江·依不拉音,等.微创McKeown食管鳞癌根治术学习曲线特点及喉返神经旁淋巴结清扫对疗效的影响[J].中华消化外科杂志,2018,17(8):825~829.
[7] 沈琼,陈陆俊,邓海峰,等.程序性死亡受体配体-1促进食管癌细胞上皮-间充质转化的研究[J].中华实验外科杂志,2019,36(2):279~281.
[8] 关嵩,王军,刘月平,等.食管鳞癌组织PD-L1表达临床意义[J].中华肿瘤防治杂志,2018,25(11):778~783.
[9] 孙楠,李源,赫捷.常见抑制性免疫检查点基因与食管鳞癌临床相关性分析[J].中华医学杂志,2018,98(21):1703~1706.
[10] 付媛媛,徐锦波,张敏等.Foxp3和CD8⁺T细胞在乳腺癌组织中的表达及与预后的关系[J].浙江医学,2019,41(17):1831~1835.
[11] 高翔,刘志宇,王梁,等.术前中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值对非肌层浸润性膀胱癌的预后评估价值[J].中国医科大学学报,2019,48(7):638~342.