糖尿病足患者病原菌分布及血清炎性因子与病情及预后的相关性分析

doi:10.3969/j.issn.1006-6233.2020.09.02

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1217 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To analyze the distribution of pathogenic bacteria in diabetic foot patients and the correlation between serum inflammatory factors and disease condition and prognosis.Methods: The clinical data of 86 diabetic foot patients admitted to Jinan Central Hospital from January 2018 to May 2019 were selected and divided into mild infection group (30 cases), moderate infection group (33 cases) and severe infection group (23 cases) according to the infection degree of diabetic foot.As to the outcome of treatment, 28 cases were cured, 44 cases were improved and 14 cases were ineffective.At the same time, 78 health controls were made the control group.The distribution of pathogenic bacteria in diabetic foot patients was analyzed.The levels of serum procalcitonin (PCT), high sensitivity C-reactive protein (hs-CRP) and interleukin -6(IL-6) in each group were compared.Results: A total of 102 strains of pathogenic bacteria were isolated from 86 patients with diabetic foot.Gram-negative bacteria were dominant, mainly Pseudomonas aeruginosa and Acinetobacter baumannii, followed by Gram-positive bacteria, mainly Staphylococcus aureus and Staphylococcus epidermidis.The levels of serum inflammatory factors in diabetic foot infection groups with different degrees were higher than those in the control group, and the difference was statistically significant (P<0.05).The level of serum inflammatory factors in diabetic foot severe infection group was significantly higher than that in moderate infection group and mild infection group (P<0.05).The levels of serum inflammatory factors in patients with diabetic foot failure were significantly higher than those in the cured and improved groups, and the difference was statistically significant (P<0.05).Conclusion: The distribution of pathogenic bacteria in diabetic foot patients is dominated by gram-negative bacteria, and the level of serum inflammatory factors increases significantly with the aggravation of infection degree.In addition, the level of serum inflammatory factors can reflect the clinical effectiveness of diabetic foot patients.

Key words： Diabetic foot Distribution of pathogenic bacteria Inflammatory factor

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Yan
	CHU Jingxue
	et al

Cite this article:

WANG Yan,CHU Jingxue,et al. Analysis of Pathogen Distribution and the Correlation Between Serum Inflammatory Factors and Disease Condition and Prognosis in Diabetic Foot Patients[J]. HeBei Med, 2020, 26(9): 1413-1416.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.09.02 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I9/1413

[1] Bursac SN, Jandric S, Talic G. Influence of diabetic distal symmetric polyneuropathy on the performance of the musculoskeletal system of lower leg and foot[J]. Med Arch, 2019,73(4):262~267.
[2] Kananizadeh P, Ohadian Moghadam S, Sadeghi Y, et al. Molecular characteristics of methicillin-resistant staphylococcus aureus (MRSA) isolated from diabetic foot infection[J]. Iran Pathol, 2019,14(4):329~337.
[3] 穆琪,钱超,常琪等.糖尿病足溃疡患者病原菌感染特征分析[J].东南国防医药,2019,21(5):460~465.
[4] Bayat M, Chien S.Combined adipose-derived mesenchymal stem cells and photobiomodulation could modulate the inflammatory response and treat infected diabetic foot ulcers[J]. Photobiomodul Photomed Laser Surg, 2020,38(3):135~137.
[5] 中国医疗保健国际交流促进会糖尿病足病分会.中国糖尿病足诊治指南[J].中华医学杂志,2017,97(4):251~258.
[6] Lee YN, Chang SO. Diabetic foot ulcer patients' uncertainty regarding their prognosis: a Q-methodological study[J].Wound Ostomy Continence Nurs, 2019,46(6):531~538.
[7] Ryan EC, Crisologo PA, Oz OK, et al. Do SIRS criteria predict clinical outcomes in diabetic skin and soft tissue infections[J].Foot Ankle Surg,2019,58(6):1055~1057
[8] MacDonald A, Brodell JD Jr, Daiss JL, et al. Evidence of differential microbiomes in healing versus non-healing diabetic foot ulcers prior to and following foot salvage therapy[J].Orthop Res, 2019,37(7):1596~1603.
[9] Tardaguila-Garcia A, Garcia-lvarez Y, Sanz-Corbalan I, et al. Role of inflammatory markers in the healing time of diabetic foot osteomyelitis treated by surgery or antibiotics[J].Wound Care, 2020,29(1):5~10.
[10] 叶云燕,王欢,王艺沙,等.血清PCT与CRP和血小板对重症感染患者病情程度的评估效果研究[J].中华医院感染学杂志,2019,29(10):1487~1490.
[11] 汪涟,郭菲,闵定宏,等.炎症与修复相关细胞因子基因在临床慢性难愈性创面中差异表达的分析[J].中华烧伤杂志,2019,35(1):18~24.
[12] 徐波,杨彩哲,吴石白,等.糖尿病足患者截肢相关危险因素分析[J].中华内科杂志,2017,56(1):24~28.