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| Protective Effect of Edaravone on Nerve Function and Its Relationship with Serum D-Dimer and Total Bilirubin Levels in Patients Undergoing Intracranial Aneurysm Clipping |
| WANG Peng, HAI Lan |
| The First People's Hospital of Tianshui, Gansu Tianshui 741000, China |
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Abstract Objective: To explore the effects of edaravone on nerve function, serum D-dimer (D-D) and total bilirubin (TBil) levels in patients undergoing intracranial aneurysm clipping, and to analyze correlation between nerve function and serum D-D, TBil levels after treatment.Methods: Sixty patients who underwent intracranial aneurysm clipping from January 2018 to September 2019 were enrolled and divided into observation group and control group with the simple random grouping method, 30 cases in each group.Both groups were given routine treatment of albumin, dopamine, low-molecular dextran, mannitol) for 10 days.On this basis, observation group was given edaravone for 14 days.NIHSS score, levels of serum D-D and TBil, and prognosis were compared between the two groups.Results: The NIHSS scores, D-D and TBil levels in the observation group before treatment and 14d after treatment were higher than those in control group (P<0.05).14d after treatment, serum D-D level was positively correlated with NIHSS score (r=0.426, P<0.05), while serum TBil level was negatively correlated with NIHSS score (r=-0.359, P<0.05).3 months after treatment, good rate of prognosis in observation group was higher than that in control group (70.00% vs 43.33%) (P<0.05).Conclusion: Edaravone treatment after intracranial aneurysm clipping can protect nerve function, which is related to changes in serum D-D and TBil levels.
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2020, Vol. 26 
