早期梅毒患者IL-1β和IL-33表达与梅毒细胞免疫的相关性研究

doi:10.3969/j.issn.1006-6233.2020.09.011

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Abstract Objective: To study the correlation between expression of interleukin-1β (IL-1β), interleukin-33 (IL-33) and syphilis cellular immunity in patients with early syphilis.Methods: Fifty patients with early syphilis (observation group) who were admitted to the hospital from July 2018 to June 2019 were enrolled as study objects.Another 50 healthy volunteers were enrolled as control group.The levels of serum IL-1β and IL-33 in both groups were detected by enzyme-linked immunosorbent assay.Flow cytometry was applied in order to detect levels of T lymphocyte subsets (CD3⁺, CD4⁺, CD8⁺) and NK cells in peripheral blood.According to measured serum IL-1β and IL-33 levels in patients with early syphilis, they were divided into high-level IL-1β group, low-level IL-1β group, high-level IL-33 group and low-level IL-33 group by dichotomy.The levels of CD3⁺, CD4⁺, CD8⁺ and NK cells in peripheral blood were compared among all groups.Pearson correlation analysis was applied in order to analyze correlation of IL-1β and IL-33 expression with cellular immunity in patients with early syphilis.Results: The levels of serum IL-1β and IL-33 in observation group were higher than those in control group (P<0.05).The levels of CD3⁺, CD4⁺, CD8⁺ and NK cells in peripheral blood in observation group were lower than those in control group (P<0.05).The levels of CD3⁺, CD4⁺, CD8⁺ and NK cells in peripheral blood in high-level IL-1β group were lower than those in low-level IL-1β group (P<0.05).The levels of CD3⁺, CD4⁺, CD8⁺ and NK cells in peripheral blood in high-level IL-33 group were lower than those in low-level IL-33 group (P<0.05).Pearson correlation analysis showed that levels of serum IL-1β and IL-33 were negatively correlated with levels of CD3⁺, CD4⁺, CD8⁺ and NK cells in peripheral blood in early syphilis patients (P<0.05).Conclusion: The levels of serum IL-1β and IL-33 are increased in early syphilis patients, which are negatively related to cellular immunity.Changes in IL-1β and IL-33 may be of certain regulatory effect on cellular immunity.

Key words： Syphilis Interleukin-1β Interleukin-33 Cellular immunity

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Cite this article:

CUI Li,et al. Correlation of IL-1β and IL-33 Expression with Syphilis Cellular Immunity in Early Syphilis Patients[J]. HeBei Med, 2020, 26(9): 1450-1454.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.09.011 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I9/1450