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| Correlation Between Plasma Cor NSE Insulin Resistance and Prognosis of Patients with Hypertensive Cerebral Hemorrhage |
| WANG Yu, ZHANG Qian, ZHANG Lei |
| The First Affiliated Hospital of PLA Air Force Military Medical University, Shaanxi Xi'an 710032, China |
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Abstract Objective: To explore the correlation between plasma Cortisol (Cor), neuron-specific enolase (NSE), insulin resistance (IR) and prognosis of patients with hypertensive cerebral hemorrhage (HCH).Methods: A total of 106 HCH patients were enrolled and divided into survival group (88 cases) and death group (18 cases) according to their prognosis.According to neurological deficit degree, they were divided into mild group (70 cases), moderate group (26 cases) and severe group (10 cases).Fifty middle-aged and elderly health controls in the same period were enrolled as control group.The levels of plasma Cor, NSE, fasting blood glucose (FBG) and fasting insulin were detected within 24h after confirming.IR index was calculated.Results: The levels of Cor and NSE, and IR index in cerebral hemorrhage group were higher than those in control group (P<0.05).Cor level in moderate group and severe group was higher than that in mild group (P<0.05).NSE level in severe group was higher than that in mild group and moderate group (P<0.05).IR index in moderate group and severe group was higher than that in mild group (P<0.05).The levels of Cor and NSE, and IR index were positively correlated with NIHSS score (r=0.325, r=0.530, r=0.336, P<0.05).The levels of Cor and NSE, and IR index in death group were higher than those in survival group (P<0.05).The high-level Cor (β=0.853, OR=2.347, 95%CI = 1.286-4.283), high-level NSE (β=0.469, OR=1.598, 95%CI=1.258-2.030) and increased IR index (β=0.543, OR=1.721, 95%CI=1.112-2.665) were positively correlated with unfavorable prognosis.Conclusion: The levels of plasma Cor and NSE, and IR are closely related to disease severity and prognosis of HCH patients.
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[1] Ziai WC, Thompson CB, Mayo S, et al. Intracranial hypertension and cerebral perfusion pressure insults in adult hypertensive intraventricular hemorrhage: occurrence and associations with outcome[J]. Crit Care Med,2019,47(8):1125~1134.
[2] Tarantini S, Valcarcel NM, Yabluchanskiy A, et al. Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype[J]. Aging Cell,2017,16(3):469~479.
[5] Esnafoglu E, Ayyldz SN, Crrk S, et al. Evaluation of serum Neuron-specific enolase, S100B, myelin basic protein and glial fibrilliary acidic protein as brain specific proteins in children with autism spectrum disorder[J]. Int Dev Neurosci,2017,10(61):86~91.
[6] Matz O, Arndt A, Litmathe J, et al. Risk factors for hypertensive and cerebral amyloid angiopathy associated intracerebral hemorrhage: a retrospective comparison[J]. Fortschr Neurol Psychiatr,2018,86(12):763~769.
[7] Eskioglou E, Huchmandzadeh M, Amiguet M, et al. National institutes of health stroke scale zero strokes[J]. Stroke,2018,49(12):3057~3059.
[8] 张平,蒋莉,刘稀金,等.H2S拮抗皮质醇诱导的大鼠抑郁症模型海马神经元及突触损伤[J].中华神经医学杂志,2017,16(10):1034~1040.
[9] 冯大磊,张继东,李靖.皮质醇对高血压性脑出血患者预后的评估价值[J].中国卫生工程学,2019,18(3):436~438.
[8] 田小军,郝洁,赵建华,等.血清铁蛋白、皮质醇及同型半胱氨酸与高血压脑出血患者预后的关系[J].临床与病理杂志,2017,37(12):2647~2652.
[9] Georgantzi K, Skldenberg EG, Stridsberg M, et al. Chromogranin A and neuron-specific enolase in neuroblastoma: correlation to stage and prognostic factors[J]. Pediatr Hematol Oncol,2018,35(2):156~165.
[10] Wang Y, Xu S, Pan S, et al. Association of serum neuron-specific enolase and bilirubin levels with cerebral dysfunction and prognosis in large-artery atherosclerotic strokes[J].Cell Biochem,2018,119(12):9685~9693.
[11] 姚芳,姜薇薇,胡春玲,等.创伤性脑损伤患儿血清神经元特异性烯醇化酶、皮质醇的水平特点及其意义[J].神经损伤与功能重建,2019,14(6):312~313. |
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2020, Vol. 26 
