|
|
The Effect of Hypotonic Contrast Agent Iohexol and Isoosmotic Contrast Agent Iodixanol on Renal Function in Enhanced CT |
LIU Yong, LING Xuefeng, CHEN Guozhang |
The People's Hospital of Haixi Autonomous Prefecture, Qinghai Delingha 817099, China |
|
|
Abstract Objective: To compare the effect of iohexol, a hypotonic contrast agent, with iodixanol, an isoosmolar contrast agent, on the renal function of patients. Methods: 80 cases of enhanced CT in the radiology department of the People's Hospital of Haixi Autonomous Prefecture from March 2018 to December 2019 were analyzed retrospectively. According to the use of different contrast agents, they were divided into the observation group and the control group, 40 cases in each group. The renal function, contrast effect and adverse reactions of the two groups were compared before and after operation. Results: The levels of SCR, UAER and BUN in the observation group were (84.32±6.42) umol /L, (83.48±10.49) mg /24h, (4.90±1.12) mmol /L, respectively, which were significantly different from those in the control group (P<0.05); the contrast results showed that the excellent and good rate in the observation group was 95.0%, in comparison with 90.0% of the other group, and the difference was not statistically significant (P>0.05). The adverse reaction in one week follow-up was found in 2 patients in the observation group, accounting 5.0%, lower than 20.0% in the control group, with statistical significance (P<0.05). Conclusion: The application of icosahol in enhanced CT can reduce the influence on renal function of patients on the basis of ensuring the contrast effect, and has few adverse reactions, which is worthy of clinical reference.
|
|
|
|
|
[1] 宋涛, 宋敏, 李勇, 等.等渗造影剂对慢性充血性心力衰竭患者介入治疗后肾功能的影响[J].中国医师进修杂志, 2017, 40(2):107~110. [2] 宋俊萍, 刘念龙, 王玉璜, 等.碘克沙醇造影剂在宝石能谱CT低剂量条件下检查的应用研究[J].中国基层医药, 2018, 25(6):716~719. [3] Aldenbratt A, Lindberg C, Svensson M K. Reduced renal function in patients with myotonic dystrophy type 1 and the association to CTG expansion and other potential risk factors for chronic kidney disease[J]. 2017, 27(11):1038~1042. [4] 徐志祥.碘克沙醇与碘海醇药品不良反应发生特点的对比分析[J].中国药物警戒, 2018, 15(2):125~128. [5] 柳玉华, 蒋敏, 曹惠红.腹部增强CT检查后不同水疗法预防造影剂对肾损伤的效果分析[J].国际泌尿系统杂志, 2018, 38(1):119~122. [6] 田美云, 张月英.碘海醇与碘克沙醇对增强CT检查患者肾功能影响的对比研究[J].中国医药, 2017, 12(3):378~381. [7] 吴效芳, 吾红光, 张美红, 等.集束化护理在增强CT检查中预防碘海醇外渗的应用[J].浙江临床医学, 2019, 21(1):120~121. |
|
|
|