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| An Analysis of the Impact of Abnormal Sperm Morphology on the Outcome of Assisted Pregnancy and Neonatal Deformity Rate During the in Vitro Fertilization Cycle |
| LIU Limin, et al |
| Huizhou Central People's Hospital, Guangdong Huizhou 516000, China |
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Abstract Objective: To evaluate the effect of abnormal sperm morphology on the outcome of assisted pregnancy and the rate of neonatal deformities during the in vitro fertilization cycle. Methods: From January 2013 to January 2020, 1820 patients were selected who were accepting assisted pregnancy during the in vitro fertilization cycle for the first time in our reproductive medical center. The percentage of normal morphological sperm of patients was measured and they were divided into three groups (<1.0%, 1.0~4.0% and> 4.0%). The outcomes of assisted pregnancy among the three groups, including clinical pregnancy rate, live birth rate, and natural abortion rate, were compared. Then the safety, including preterm birth, infant weight and deformity rate, were further compared. Results: The three groups included 145, 726, and 949 cases, respectively. There was no significant difference in general information (age of women, body mass index, basic FSH, age of men and infertility years.) among the three groups before assisted pregnancy (P>0.05); the percentage of morphological sperm had no significant effect on the outcomes of assisted pregnancy, such as clinical pregnancy rate, live birth rate and spontaneous abortion rate. Follow-up of 777 deliveried couples showed that there was no statistical difference in preterm birth rate and infant weight among the three groups (P>0.05), and abnormal sperm morphology will not increase the deformity rate of the newborn. Conclusion: Abnormal sperm morphology did not affect the assisted pregnancy outcome (including clinical pregnancy rate, live birth rate and spontaneous abortion rate), nor the safety of the newborn (including premature birth, infant weight and deformity rate). The study could provide certain reference for the safety of patients with abnormal sperm morphology on selecting assisted pregnancy.
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2020, Vol. 26 
