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| Study on the Antibacterial Activity and Reverse Drug Resistance of Compound Honggen Grass Tablet and Its Components against Multidrug Resistant Bacteria |
| HU Junhui, WANG Ying, et al |
| The Affliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
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Abstract Objective: To provide the basis for the antibacterial treatment of traditional Chinese medicine, the in vitro antibacterial activity and reverse drug resistance of 5 kinds of Chinese herbal medicines in compound honggencao tablet and its formulation were studied. Methods: The mic value of the drug-resistant bacteria, Acinetobacter baumannii and Klebsiella pneumoniae, isolated from the sputum of the inpatients, was determined by the method of broth dilution, and the index of combined use ∑ FIC was calculated to judge whether the drug resistance was reversed or not. Results: In vitro antibacterial activity test showed that compound Honggen tablet had no antibacterial effect on Acinetobacter baumannii and had antibacterial effect on Klebsiella pneumoniae. The reverse drug resistance test showed that the compound honggencao tablet had synergistic effect with imipenem, cefoperazone sulbactam and gentamycin respectively. The Chinese herbal medicines with imipenem, cefoperazone sulbactam, gentamycin and cefepime respectively had different synergistic effect on Klebsiella pneumoniae. Conclusion: Compound honggencao tablet and its compound 5 are Chinese herbal medicines, which have certain effect on antibacterial activity and reverse drug resistance of multi drug resistant Klebsiella pneumoniae.
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2020, Vol. 26 
