|
|
|
| A Clinical Study on Changes of Serum NT-proBNP BMP-7 and TGF-β1 Levels in Premature Infants with Respiratory Distress Syndrome |
| QI Changli, et al |
| Qionghai People's Hospital, Hainan Qionghai 571400, China |
|
|
|
|
Abstract Objective: To explore the clinical study on changes of serum Amino-terminal pro-brain natriuretic peptide (NT-proBNP), Bone morphogenetic protein -7 (BMP-7) and Transforming growth factor-β1 (TGF-β1) levels in premature infants with respiratory distress syndrome (RDS). Methods: A total of 106 premature infants with RDS diagnosed in the hospital from April 2016 to April 2018 were selected, and another 53 premature infants with non-RDS of the same age group at the same time period were collected as control group. The expression levels of NT-proBNP, BMP-7 and TGF-β1 in serum samples of premature infants were detected by ELISA in the two groups. The correlation between NT-proBNP, BMP-7 and TGF-β1 and disease severity was analyzed by Pearson correlation analysis. The ROC curve was used to analyze its diagnostic value for RDS. Results: Compared with control group, the expression levels of BMP-7, NT-proBNP and TGF-β1 in serum of RDS patients were significantly increased (P<0.05). Serum NT-proBNP, BMP-7 and TGF-β1 in premature infants with RDS were positively correlated with disease severity (r=0.402, P=0.000; r=0.311, P=0.018; r=0.313, P=0.015). The cut-off value, sensitivity, specificity and AUC of NT-proBNP in the diagnosis of premature infants with RDS were 3655.92 ng/L, 88.7%, 3.8% and 0.985. The cut-off value, sensitivity, specificity and AUC of BMP-7 diagnosis were 44.85 ng/L, 63.2%, 11.3% and 0.829. The cut-off value, sensitivity, specificity and AUC of TGF-β1 diagnosis were 36.73 g/L, 81.1%, 17.0% and 0.829. The sensitivity, specificity and AUC of BMP-7 combined with TGF-β1 were 89.6%, 15.1% and 0.934. Conclusion: The levels of serum NT-proBNP, BMP-7 and TGF-β1 in RDS patients are significantly increased, and their expression levels are positively correlated with disease severity, and they are expected to be diagnostic and prognostic markers.
|
|
|
|
|
|
[1] Terragni P P,Rosboch G,Tealdi A,et al.Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome[J].Am Respir Crit Care Med,2016,175(2):160~166.
[2] Bellani G,Laffey J G,Pham T,et al.Epidemiology,patterns of care,and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries[J].Jama,2016,315(8):788~800.
[3] Wang J Y,Yeh T F,Lin Y J,et al.Early postnatal dexamethasone therapy may lessen lung inflammation in premature infants with respiratory distress syndrome on mechanical ventilation.[J].Pediatric Pulmonology,2015,23(3):193~197.
[4] Zachariah J P,Twalib A,Amy S,et al.Amino-terminal pro-brain natriuretic peptide in children with latent rheumatic heart disease:[J].Annals of Pediatric Cardiology,2016,9(2):120~125.
[5] Yu Z,ZaiChun X,WunLun H,et al.BMP-7 attenuates TGF-β1-induced fibronectin secretion and apoptosis of NRK-52E cells by the suppression of miRNA-21.[J].Oncol Res,2015,23(4):147~154.
[6] 肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].第4版.北京:人民出版社,2011.395~398.
[7] Jorch G,Hartl H,Roth B,et al.To the editor:surfactant aerosol treatment of respiratory distress syndrome in spontaneously breathing premature infants[J].Pediatr Pulmonol,2015,24(3):222~224.
[8] 陆俊秀,杨冰岩,赖春华,等.呼吸窘迫综合征早产儿小剂量利尿剂治疗前后血清NT-proBNP及IL-6水平的变化及意义[J].广东医学,2018,39(z1):231~233,236.
[9] 赵文飚,万晟霞,顾德芳.糖皮质激素雾化吸入对呼吸窘迫综合征患者肺纤维化的疗效观察[J].解放军医学杂志,2014,39(9):741~745.
[10] 李小琴,郑玲芳.新生儿呼吸窘迫综合征患儿血清TGF-β1及BMP-7的表达及意义[J].中国当代儿科杂志,2015,17(5):445~448. |
|
|
|
2020, Vol. 26 
