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| Analysis of clinical and pathological characteristics in adults patients with ANCA associated vasculitis and renal involvement |
| TANG Hailian, LI Jianjun, BI Jie, et al |
| Beidaihe Rehabilitation and Recuperation Center of PLA, Hebei Qinhuangdao 066100, China |
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Abstract Objective: To investigate the clinical and pathological characteristics of different age groups in adults with ANCA-associated vasculitis and renal damage. Methods: 76 adult patients (age ≥ 18 years) were selected and divided into groups according to age. The patients with age ≥ 60 years old were 36 cases in the elderly group, including 12 males and 24 females; the patients with age ≤ 18 years old < 60 years old were 40 cases in the young and middle age group, including 13 males and 27 females. The clinical data and renal pathological results of the two groups were retrospectively analyzed. Results: In adult patients with ANCA associated vasculitis and renal damage,the clinical manifestations of cough, moderate to severe renal insufficiency, anemia, hypertension and gross Hematuria in the observation group were significantly higher than those in the control group (P<0.05). The pathological types of the two groups were mainly segmental type, and the old aged group accounted for 36.1%, the Middle-aged young group accounted for 67.5%; apart from segmental type, crescentic and scleorotic typeswas more common, accounted for 27.8% and 22.2% in the observation group; crescentic type accounted for 20.0% in the control group. The prevalence of crescent formation, glomerular scleorosis, interstitial fibrosis and tubular atrophy were significantly higher in the observation group than those in the control group, and the differences were statistically significant (P<0.01). Conclusions: The clinical manifestations of elderly patients with renal impairment of ANCA-associated vasculitis are more complicated, especially in the aspects of respiratory system and renal function. With various pathological types, both active and chronic renal lesions in the elderly patients are significant. Severe glomerular damage and tubulointerstitial damage are common.
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2020, Vol. 26 
