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| The Diagnostic and Therapeutic Values of Fungal D-glucan Detection in COPD Patients with Invasive Pulmonary Fungal Infection |
| ZHOU Anwen, YUAN Hongxia |
| The First People's Hospital of Chenzhou City, Hunan Chenzhou 423000, China |
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Abstract Objective: To explore the diagnostic and therapeutic value of fungal d-glucan test (G test) for invasive pulmonary fungal infection (IPFI) in patients with chronic obstructive pulmonary disease (COPD). Methods: 200 patients with COPD diagnosed as IPFI from June 2017 to June 2019 in our hospital were selected as the research object. With fungal culture and smear positive results taken as the gold standard, all of the patients took G test, and sensitivity and specificity were calculated before analyzing the D-glucan content in valid and invalid cases. Results: Among the 200 patients to be diagnosed with IPFI, the results of fungal culture and smear were taken as the standard, and a total of 142 positive IPFI patients and 58 negative IPFI patients were detected. A total of 132 patients with positive IPFI and 68 patients with negative IPFI were detected by G test. The ROC curve showed that the AUC of G test for the diagnosis of COPD patients with IPFI was 0.904, the sensitivity was 89.43%, the specificity was 91.38%, and the accuracy was high. During the course of treatment, 118 patients (83.10%) were treated effectively, while 24 patients (16.90%) were not treated effectively. Further measurement of G test value showed no statistically significant difference between the two groups before treatment (P>0.05). After 1 and 2 weeks of treatment, G test value of the effective group significantly decreased, with statistically significant difference (P<0.05). Conclusion: The accuracy of plasma G test in diagnosing fungal bloodstream infection is relatively high, which has a good positive predictive value for the early diagnosis of fungal bloodstream infection, and has certain clinical guiding significance for predicting the treatment effect of patients.
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2020, Vol. 26 
