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| The Curative Effect of Modified PPH on Circumferential Mixed Hemorrhoid of Connective Tissue Type and Its Influences on Serum HIF-1a VEGF and MMP-9 Levels |
| LIANG Jiadi, SU Jinhua, LI Xiaolan |
| Dongguan People's Hospital, Guangdong Dongguan 523000, China |
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Abstract Objective: To explore curative effect of modified procedure for prolapse and hemorrhoids (PPH) on circumferential mixed hemorrhoid of connective tissue type and its influences on levels of serum hypoxia-inducible factor-1a (HIF-1a), vascular endothelial growth factor (VEGF) and matrix metalloproteinase 9 (MMP-9). Methods:The clinical data of 80 patients with circumferential mixed hemorrhoid of connective tissue type who were admitted to the hospital from September 2018 to June 2019 were retrospectively analyzed. According to different treatment methods, they were divided into control group (n=40) and observation group (n=40).The control group was treated with traditional Milligan-Morgan, while observation group was treated with modified PPH. The perioperative indexes, clinical curative effect, score of visual analogue scale (VAS), levels of serum HIF-1a, VEGF and MMP-9, incidence of complications and anal function score were compared between the two groups. Results:The operation time, hospitalization time and wound healing time in observation group were shorter than those in control group, and intraoperative blood loss was less than that in control group (P<0.05). The total response rate in observation group was higher than that in control group (95.00% VS 77.50%) (P<0.05). After treatment, VAS scores in observation group were lower than those in control group(P<0.05). After treatment, levels of serum HIF-1a, VEGFand MMP-9 in observation group were lower than those in control group(P<0.05). The incidence of complications in observation group was lower than that in control group (7.50% VS 30.00%) (P<0.05). The anal function score in observation group was lower than that in control group (P<0.05). Conclusion:The curative effect of modified PPH is significant on circumferential mixed hemorrhoid of connective tissue type, which can alleviate pain, reduce levels of serum HIF-1a, VEGF and MMP-9, improve anal function, with high safety.
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2020, Vol. 26 
