|
|
Diagnostic Value of Combined Detection of G Test and GM Test in Invasive Fungal Infections in Patients with Hematologic Malignancies |
XU Jianli, CHEN Gang, GU Libadanmu, et al |
The First Affiliated Hospital of Xinjiang Medical University / Xinjiang Uygur Autonomous Region Institute of Hematology, Xinjiang Urumqi 830054, China |
|
|
Abstract Objective: To explore diagnostic value of combined detection of (1,3)-β-D-glucan (G test) and galactomannan antigen (GM test) for invasive fungal infections (IFI) in patients with hematologic malignancies. Methods: A total of 178 patients with hematologic malignancies who were admitted to the hospital from June 2018 to June 2019 were enrolled. According to traditional clinical diagnosis results, they were divided into IFI group (50 cases) and non-IFI group (128 cases). All underwent G test and GM test. The receiver operating characteristic (ROC) curves were applied to analyze critical values of G test and GM test. The value of G test, GM test and their combination for diagnosis of IFI and diagnosis time were analyzed. Results: ROC curve analysis showed that critical values of G test and GM test were 147.37 pg/mL and 0.88 ug/L, respectively. Compared with G test alone or GM test alone, sensitivity of combined diagnosis for IFI was significantly improved (P<0.05). Compared with clinical diagnosis, G test, GM test and their combination can shorten IFI diagnosis time (P<0.05). Conclusion: The combined detection of G test and GM test can effectively improve diagnostic sensitivity of patients with hematologic malignancies and IFI, and shorten waiting time of diagnosis.
|
|
|
|
|
[1] 赵蔚,孙芳.327例恶性血液病合并侵袭性真菌病患者的临床分析[J].中国真菌学杂志,2017,12(6):346-351. [2] 王美璐,匡慧慧,程龙灿,等.海南热带地区恶性血液病患者肺部真菌和其他病原菌感染特征单中心分析[J].中国实验血液学杂志,2018,26(3):911~916. [3] Derek Murrell,John B.Bossaer,Ronald Carico,et al.Isavuconazonium sulfate:a triazole prodrug for invasive fungal infections[J].Int J Pharm Pract.2017,25(1):18~30. [4] Jiang-Hong C,Guang-Hui L I.Revised definitions of invasive fungal disease from the european organization for research and treatment of cancer/invasive fungal Infections cooperative group and the national Institute of allergy and infectious diseases mycoses study group(EORTC/MSG)Co[J].Infect Chemother,2008,8(5):321~324. [5] 田磊,王继军,景红梅,等.恶性血液病患者合并血流感染的临床和病原学特征[J].中国感染与化疗杂志,2017,17(5):504~508. [6] Kobayashi,Ryoji,Hori,Daiki,Sano,Hirozumi,et al.Risk factors for invasive fungal Infection in children and adolescents with hematologic and malignant diseases:a 10-year analysis in a single institute in japan[J].Pediatr Infect Dis,2018,37(12):1282~1285. [7] Pengfei Zhu,Jun Lv,Yongkui Kong,et al.Absolute eosinophil count was significantly associated with serum(1,3)-β-D-glucan in patients with invasive fungal infections[J].Clin Lab,2017,63(4):749~756. [8] 陈婷婷,刘永林,钱煦岱,等.G试验联合GM试验诊断恶性血液病患者侵袭性真菌病的价值[J].浙江临床医学,2018,20(1):122~124. [9] Furfaro E,Viscoli C,Giacobbe D R,et al.The beta-d-glucan test:time to re-visit Its utility in IFI diagnosis[J].Curr Fungal Infect Rep,2015,9(4):292~301. [10] Azoulay E,Guigue N,Darmon M,et al.(1,3)-β-D-glucan assay for diagnosing invasive fungal infections in critically ill patients with hematological malignancies[J].Oncotarget,2016,7(16):21484~21495. [11] 陆书华,钱震雯,孔庆丽,等.G试验联合GM试验对恶性肿瘤患者并发侵袭性真菌感染的早期诊断价值[J].国际检验医学杂志,2017,38(14):1956~1957. [12] 王霞,高岭.G试验联合GM试验在儿童恶性血液病侵袭性真菌感染的诊断价值[J].江苏医药,2016,42(18):2027~2029. |
|
|
|