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| Clinical Significance of Corona Virus Disease 2019(COVID-2019)T lymphocyte Subsets |
| WU Wei, HUANG Hesong, YU Qiao, et al |
| General Hospital of the Central Theater of the PLA, Hubei Wuhan 430070, China |
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Abstract Objective: To investigate novel coronavirus pneumonia T lymphocyte subsets and its clinical significance. Methods: 88 novel coronavirus pneumonia patients were selected as the observation group, and 30 healthy people as control group. There was no significant difference in gender and age between the two groups (P > 0.05).The T lymphocyte subsets were detected by flow cytometry, and their clinical significance was analyzed. Results: The absolute numbers of CD4 + and CD8 + in peripheral blood of 88 patients were 335.000 (196.000,499.000) and 223.000 (118.000,324.000) respectively, which were significantly lower than those of healthy control group (1027.933 ± 235.014 and 727.033 ± 210.633), the difference between groups was statistically significant (P<0.01) There was no significant difference in the percentage of CD4 +, CD8 + and the ratio of CD4 + / CD8 + between the two groups (P>0.05). There was significant difference in the absolute number of CD4 + and CD8 + T cells among the three groups (P<0.01). ROC analysis showed that CD4 + and CD8 + had clinical significance in judging disease aggravation, and the best critical values were 362 / UL and 222 / UL respectively. Conclusion: The absolute numbers of CD4 + and CD8 + T in the peripheral blood of COVID-2019 are reduced to some extent, which may help to predict the development and prognosis of the disease and guide the clinical treatment.
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2020, Vol. 26 
