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| Analysis of Logistic Factors Influencing the Prognosis of Severe Neonatal Hypoxic-ischemic Encephalopathy |
| WENG Haimei, LIN Mingjing, ZHOU Lixia |
| Hainan People's Hospital, Hainan Haikou 570311, China |
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Abstract Objective: To explore the related factors that affected the prognosis of severe hypoxic-ischemic encephalopathy (HIE). Methods: A total of 134 children with severe HIE who were treated in our hospital from January 2016 to April 2019 were enrolled. All patients were followed up for 6 months without any loss of follow-up. According to the prognosis, the children were divided into a good prognosis group and a poor prognosis group. The clinical data of the children were collected. The factors affecting the prognosis of children with severe HIE were analyzed by single factor and multivariate logistic regression. Results: The follow-up results showed that the prognosis was good in 103 cases (76.87%), and the prognosis was poor in 31 cases (23.13%). The prognosis group included 4 deaths, accounting for 2.99%.Univariate analysis showed that the 5 min Apgar score, organ injury, starting treatment age, and serum tau protein levels were significantly different between the patients with severe HIE prognosis and those with poor prognosis (P<0.05). There was no significant difference in gestational age, birth weight, mode of delivery, and 1 min Apgar score (P>0.05).Multivariate logistic regression analysis showed that 5 min Apgar score ≤ 3 points (OR=58.658, 95% CI=6.984~492.682), organ damage ≥ 2 (OR=31.145, 95%CI=3.522~275.415), starting treatment Age≥48h (OR=33.747, 95% CI=5.992~190.066), serum tau ≥8ng/L (OR=5.846, 95% CI=1.372~24.918) are risk factors for the prognosis of children with severe HIE (all P<0.05). Conclusion: Patients with 5 min Apgar score ≤ 3, organ injury ≥ 2, age ≥ 48h, and serum tau protein ≥ 8ng / l have a higher risk of poor prognosis. Therefore, clinical monitoring and timely intervention should be strengthened.
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2020, Vol. 26 
