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| Relationship Between Levels of Serum UA, CK, Cys-C and APN and Carotid Atherosclerosis in Elderly Patients with Hypertension |
| MA Zhan, LEI Hailing, SUN Huayi |
| Beijing Jishuitan Hospital, Peking University, Beijing 100035, China |
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Abstract Objective: To analyze the relationship between levels of serum uric acid (UA), creatine kinase (CK), cystatin C (Cys-C), adiponectin (APN) and carotid atherosclerosis in elderly patients with hypertension. Methods: A total of 110 elderly patients with hypertension admitted to our hospital from April 2018 to April 2019 were selected for the study. The patients were divided into normal IMT group (36 cases), IMT thickening group (31 cases) and plaque formation group (43 cases) according to the carotid intima-media thickness (IMT). The levels of serum UA, CK, Cys-C and APN were detected, and the correlation between IMT and above indicators was analyzed, and the factors affecting carotid atherosclerosis in elderly hypertensive patients were analyzed by Logistic regression model. Results: With the increase of IMT thickening, the levels of serum UA, CK and Cys-C were increased gradually, and the levels showed normal IMT group<IMT thickening group<plaque formation group (P<0.05), and the APN level was gradually decreased, and the level showed normal IMT group>IMT thickening group>plaque formation group (P<0.05). Pearson correlation analysis showed that IMT was positively correlated with UA, CK and Cys-C (P<0.05), and was negatively correlated with APN (P<0.05). Binary Logistic regression model analysis showed that serum UA, CK, Cys-C and APN were independent risk factors for carotid atherosclerosis in elderly hypertensive patients (P<0.05). Conclusion:The degree of carotid atherosclerosis in elderly hypertensive patients is related to the increases of serum UA, CK and Cys-C and the decrease of APN.
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2020, Vol. 26 
