|
|
The Repairing Effect of CGF Combined with Fibroin Hydroxyapatite Scaffold on Rabbit Mandible Defect |
CHEN Qi, LI Shiyan, YU Xin |
Chengde Central Hospital, Hebei Chengde 067000, China |
|
|
Abstract Objective: To explore the role of concentrated growth factor (CGF) complex silk fibroin-hydroxyapatite scaffold in promoting the repair of rabbit mandibular defects. Methods: 48 healthy New Zealand white rabbits were randomly divided into 3 groups, 16 in each group. The right mandibular bone defect model was prepared at the same time. Group A was a composite material group, and group B was a hydroxyapatite group implanted with hydroxyapatite materialGroup C No material is implanted for the blank group. All animals were harvested at 2, 4, 8, and 12 weeks, and tissue samples were prepared. The results were observed in general observation, imaging, and histological analysis. The imaging analysis values were collected and evaluated. The analysis results were analyzed by SPSS17.0. P<0.05 was statistically significant. Results: Gross observation and imaging analysis showed that the new bone condition and osteogenesis rate of group A were significantly better than those of the other two groups. The bone mineral density analysis and new bone area measurement also showed the superiority of composite materials in promoting osteogenesis. Conclusion: Concentrated growth factor (CGF) combined with silk fibroin hydroxyapatite scaffolds showed a good osteogenic effect in the experiment of promoting jaw defects, with obvious osteoinductive effect, which is expected to become a new material for clinical bone defect repair.
|
|
|
|
|
[1] 俊毅,司微杭,刘瑾,等.CGF复合骨诱导活性材料在牙周炎患牙位点保存中的应用[J].陕西医学杂志,2016,45(6):697~699. [2] 陈飞,潘韶霞,冯海兰.转化生长因子-Bl和血管内皮生长因子在浓缩生长因子各层中的分布及含量特点[J].北京大学学报:医学版,2016,48(5):860~865. [3] QinJ,wangL,zhengL,et al.Concentraledgrowthfacto pmmoles schwann ceumigmtionpoiylhmugh the jntegnn p1-medialed activation of the focaI adhesion kinase pathway[J].InI Mol Med, 2016,37(5):1363~1370. [4] liramaji S,Zamanian A,Mozafari M. Super-paramagnetic responsive silk fibroin/chitosan/magnetite scaffolds with tunable pore structures for bone tissue engineering applications[J].Materials Science & Engineering C-Materials for Biological Applications, 2017,70( 1) : 736~744. [5] Ran J,Hu J,Sun G,et al. A novel chitosan-tussah silk fibroin / nano-hydroxyapatite composite bone scaffold platform with tunable mechanical strength in a wide range[J].International Journal of Biological Macromolecules,2016,93(11) : 87~97. [6] 罗三莲,童昕,高太智,等.浓缩生长因子复合Bio-oss骨粉对前牙三壁骨缺损患者种植疗效及新骨形成影响[J].山东医药,2015,(33):8~10. [7] 伏钰,陈丽,周莉,等.聚乙烯醇/纳米羟基磷灰石/丝素蛋白复合水凝胶的制备及其性能研究[J].化学研究与应用,2019,(04):684~689. |
|
|
|