脓毒性休克患者发生急性肾损伤危险因素的Meta分析

doi:10.3969/j.issn.1006-6233.2020.03.027

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (2788 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To analyze the risk factors of acute kidney injury in patients with septic shock, and to provide reference for early detection of high-risk population and timely prevention of acute kidney injury. Methods: Computer-reviewed literature on risk factors for acute kidney injury in patients with septic shock in CNKI, Wanfang Data Knowledge Service Platform, VIP, CBM, PubMed, Web of Science, The Cochrane Library,using RevMan5.3 to analyze. Results: Nine articles were included, including two cohort studies and seven case-control studies, age [WMD=1.33, 95% CI (-1.73, 4.38), P=0.39], smoking [OR=1.43, 95% CI (1.08, 1.87), P=0.01], drinking [OR=0.90, 95% CI (0.77,1.05), P=0.19], hypertension [OR=1.39, 95% CI (1.19,1.62), P<0.0001], diabetes [OR=1.53, 95% CI (1.38,1.69), P<0.00001], mechanical ventilation [OR= 1.30, 95% CI (1.13, 1.48), P=0.0002], the use of pressure-boosting drugs [OR=2.51, 95% CI (1.35, 4.64).P=0.003],blood transfusion history[OR=3.55,95% CI (1.82,6.91),P=0.0002],contrast medium [OR=3.44, 95% CI (2.03, 5.84), P<0.00001], blood culture positive [OR=1.59, 95% CI (1.17,2.15),P=0.003], APACHEⅡ [WMD=1.96,95% CI (1.49,2.43), P<0.00001], CVP [WMD=3.55, 95% CI (2.89,4.21), P<0.00001]. Conclusion: According to the existing evidence, the risk factors of acute renal injury in septic shock patients are smoking, hypertension, diabetes, mechanical ventilation, use of booster drugs ≥ 2 kinds, blood transfusion history, contrast media, positive blood culture, high Apache Ⅱ score, high CVP.

Key words： Septic shock Acute renal injury Risk factors Meta-analysis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.03.027 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I3/463

[1] Rhodes A,Evans L E, Alhazzani W,et al.Surviving sepsis campaign:international guidelines for management of sepsis and septic shock: 2016[J].Critical Care Medicine, 2017,43(3):486~552.
[2] Poston J T,Koyner J L.Sepsis associated acute kidney injury[J].BMJ,2019,364:1~17.
[3] Bagshaw S M,Lapinsky S,Dial S,et al.Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy[J].Intensive Care Medicine,2009,35(5):871~881.
[4] Sood M,Mandelzweig K,Rigatto C,et al. Non-pulmonary infections but not specific pathogens are associated with increased risk of AKI in septic shock[J].Intensive Care Medicine,2014,40(8):1080~1088.
[5] 殷俊,俞凤.感染性休克伴急性肾损伤的临床研究[J].安徽医药,2015,(8):1499~1502.
[6] 潘田君,杨玲飞.感染性休克伴急性肾损伤的危险因素及其预后相关因素分析[J].中国现代医学杂志,2017,27(17):98~102.
[7] 谢逢春,刘凤鸣,黄彬,等.感染性休克致急性肾损伤的危险因素分析[J].海南医学,2015,26(1):98~100.
[8] 叶素华.感染性休克致急性肾损伤的危险因素探讨[J].中外女性健康研究,2016,(16):63.
[9] 李荣,赵荣,谢秀华.ICU感染性休克患者伴急性肾损伤发生及预后影响因素分析[J].中国医学前沿杂志(电子版),2018,10(10):147~150.
[10] 刘小明,吴广礼,黄旭东,等.老年急性肾损伤的临床特点及预后危险因素分析[J].临床误诊误治,2018,31(3):99~102.
[11] Hartmann C,Groger M,Noirhomme JP,et al.In-depth characterization of the effects of cigarette smoke exposure on the acute trauma response and hemorrhage in mice[J].Shock,2019,51(1):68~77.
[12] 陈素芬,赵玉兰,黄亚萍,等.原发性高血压患者口服葡萄糖耐量试验血糖水平与早期肾损伤的关系[J].医学研究生学报,2019,32(1):88~92.
[13] 张春,邸莹,李娜,等.肝移植后早期中心静脉压水平与各器官功能之间的关系[J].中华器官移植杂志,2017,38(10):584~588.