序贯化疗联合<sup>125</sup>I放射性粒子植入对复发型宫颈癌患者的疗效及生活质量影响

doi:10.3969/j.issn.1006-6233.2020.02.017

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Abstract Objective: To investigate the effect of sequential chemotherapy combined with ¹²⁵I radioactive seed implantation on the efficacy and quality of life of patients with recurrent cervical cancer. Methods: 95 patients with recurrent cervical cancer admitted to our hospital from January 2012 to July 2019 were enrolled. According to the simple random stratification method, 50 cases were divided into study group and 45 cases in control group. Sequential chemotherapy (4 courses) was used in the control group, and the study group was treated with sequential chemotherapy combined with ¹²⁵I radioactive seed implantation. One month after treatment, the clinical efficacy, clinical benefit response (CBR), and quality of life (QLQ-C30 score) were compared between the two groups. Results: The total effective rate (78.00%) and local control rate (90.00%) in the study group were higher than those in the control group (55.56%, 71.11%), and the difference was statistically significant (P<0.05). CBR analysis showed that the patients in the study group recovered significantly, the body mass increased significantly, and the pain degree was significantly reduced, accounting for 74.00%, 78.00%, and 82.00%, respectively, which was higher than the control group’s 46.67%, 51.11%, and 40.00%. The difference was statistically significant (P<0.05).There was no significant difference in the scores of QLQ-C30 between the two groups before treatment (P>0.05). After treatment, the single item and symptom area scores of the study group were lower than the control group, and the functional areas and overall health scores were higher than the control group. The difference was statistically significant (P<0.05). Conclusion: Sequential chemotherapy combined with ¹²⁵I radioactive seed implantation can improve the therapeutic effect and clinical benefit rate of patients with recurrent cervical cancer, and promote the improvement of patients' quality of life.

Key words： ¹²⁵I Particle implantation Recurrent cervical cancer Sequential chemotherapy Efficacy Quality of life

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	CHEN Yongfu
	HE Yaowu
	LI Jian

Cite this article:

CHEN Yongfu,HE Yaowu,LI Jian. Effect of Sequential Chemotherapy Combined with ¹²⁵I RadioactiveSeed Implantation on the Efficacy and Quality of Life of Patients with Recurrent Cervical Cancer[J]. HeBei Med, 2020, 26(2): 244-247.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.02.017 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I2/244

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