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| Effect of Nalmefene Hydrochloride Combined with Mouse Nerve Growth Factor in Newborns with Hypoxic Ischemic Encephalopathy and Its Influence on Background Electroencephalogram Activity and Prognosis |
| DING Lili, WANG Jun |
| Xuzhou Children's Hospital, Jiangsu Xuzhou 221000, China |
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Abstract Objective: To explore the effect of Nalmefene hydrochloride combined with mouse nerve growth factor (mNGF) in newborns with hypoxic ischemic encephalopathy (HIE), and to analyze on its influence on background electroencephalogram activity and prognosis. Methods: 104 cases of neonatal HIE were selected as subjects and divided into routine group and combined group by simple randomization method. The routine group was given basic support and mNGF therapy. The combined group was given basic support + mNGF + Nalmefene hydrochloride. Background electroencephalogram activity changes before and after treatment, clinical effect, drug adverse reactions and sequel were compared. Results: There was no significant difference in baseline data between the two groups (P> 0.05). After treatment, the incidences of resting, burst-suppression, low voltage, diffuse americium wave and single-rhythm discharges in the two groups decreased significantly (P< 0.05). After treatment, the incidences of abnormal electroencephalogram activity in the combined group were significantly lower than those in the routine group (P< 0.05). The total effective rate was 88.00% in the combined group, which was significantly higher than that of 70.00% in the routine group (P< 0.05). There was no significant difference in the incidence of every drug adverse reaction and total drug adverse reactions between the two groups (P> 0.05). The incidences of epilepsy and total poor prognosis in the combined group were 4.00% and 4.00%, respectively, which were significantly lower than those of 14.00% and 16.00% in the routine group (P< 0.05). Conclusion: Nalmefene hydrochloride combined with mNGF for neonatal HIE can significantly improve electroencephalogram activity, achieve ideal effect, safety and reliability, and effectively reduce adverse prognosis.
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[1] Nemati H, Karimzadeh P, Fallahi M. Causes and factors associated with neonatal seizure and its short-term outcome: a retrospective prognostic cohort study[J]. Iran Child Neurol, 2018, 12(3):59~68.
[2] Copeland H, Newcombe J, Yamin F, et al. Role of negative pressure wound care and hyperbaric oxygen therapy for sternal wound infections after pediatric cardiac surgery[J]. World Pediatr Congenit Heart Surg, 2018, 9(4):440~445.
[3] 尹丽敏,李明,茹彩旺.盐酸纳美芬治疗足月新生儿缺氧缺血性脑病效果观察[J].中国乡村医药,2016,23(6):17~18.
[4] Carreras N, Alsina M, Alarcon A, et al. Efficacy of passive hypothermia and adverse events during transport of asphyxiated newborns according to the severity of hypoxic-ischemic encephalopathy[J].Pediatr (Rio J), 2018, 94(3):251~257.
[5] Arnaez J, Garcia-Alix A, Arca G, et al. Population-based study of the national implementation of therapeutic hypothermia in infants with hypoxic-ischemic encephalopathy[J]. Ther Hypothermia Temp Manag, 2018, 8(1):24~29.
[6] Arnaez J, Garcia-Alix A, Arca G, et al. Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain[J]. An Pediatr (Barc), 2018, 89(1):12~23.
[7] 张绍鹏,陈文才,李丽亚,等.高压氧联合鼠神经生长因子治疗婴幼儿脑性瘫痪疗效观察[J].中华航海医学与高气压医学杂志,2018,25(1):59.
[8] Crosio A, Fornasari BE, Gambarotta G, et al. Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects[J]. Neural Regen Res, 2019, 14(6):1079~1084.
[9] 乔健,姜东林,陈小倩,等.盐酸纳美芬对新生儿缺氧缺血性脑病的保护作用[J].儿科药学杂志,2015,21(9):4~6. |
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2020, Vol. 26 
