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| Meta-analysis of the Relationship between the Expression Level of GINS and the Prognosis of Tumor Patients |
| WANG Shibo, et al |
| The Second Hospital of Hebei Medical University, Hebei Shijiazhuang 050000, China |
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Abstract Objective: To evaluate the relationship between GINS expression levels and the prognosis of tumor patients used by meta-analysis. Methods: The articles about the relationship between the expression level of GINS and the prognosis of cancer patients in Wanfang medical network, VIP database and PubMed database were retrieved. The retrieval time was up to April 30, 2019, and the meta-analysis was carried out with Revman 5.3 software. Results: 7 articles including 722 patients included in the study about the relationship between GINS gene expression levels and overall survival (OS), the results showed high GINS gene expression of tumor patients significantly shortened OS (HR = 2.11, 95% CI 1.43 ~ 3.10, P = 0.0002);3 articles including 991 patients included in the study about the relationship between GINS gene expression levels and disease-free survival (DFS), the results showed high GINS gene expression of tumor patients significantly shortened DFS (HR = 1.60, 95% CI 1.38 ~ 1.86, P = 0.00001). Conclusion: The high expression of GINS gene has a certain relationship with the poor prognosis of tumor patients, suggesting that GINS may be a potential target for tumor prognosis.
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2020, Vol. 26 
