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| Changes of Serum IL-17 Th17 and Treg Cells in Patients with Acute Exacerbation of COPD before and after Treatment and the Correlation with Lung Function |
| WU Guixiong, ZHU Shuiquan, DONG Shufeng, et al |
| Wuzhou People's Hospital, Guangxi Wuzhou 543002, China |
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Abstract Objective: To observe the changes of serum interleukin-17 (IL-17), Th17 cells and regulatory T cells (Treg) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) before and after treatment, and explore their correlation with lung function. Methods: 300 patients with AECOPD (AECOPD group) and 100 healthy controls (control group) were selected. The levels of serum Th17,Treg cells and IL-17 levels were detected by flow cytometry. and lung function was detected to obtain indicators such as the forced expiratory volume in 1s (FEV1), forced vital capacity (FVC) and FEV1/FVC. Results: Serum IL-17, Th17 cells and Th17/Treg ratio in AECOPD group were significantly higher than those in the control group (P<0.05). Serum IL-17, Th17 cells and Th17/Treg ratio in AECOPD group significantly decreased after treatment (P<0.05) while Treg cells increased significantly (P<0.05), with significant differences between groups (P<0.05). Pearson correlation analysis showed that serum Th17, IL-17 and Th17/Treg ratio in patients with AECOPD were negatively correlated with FEV1, FVC and FEV1/FVC before and after treatment (P<0.05) while Treg cells were positively correlated with FEV1, FVC and FEV1/FVC (P<0.05). ROC curve analysis showed that the areas under curves of serum Th17, Treg, Th17/Treg and IL-17 levels for predicting death of patients with AECOPD were 0.840, 0.812, 0.975 and 0.880, respectively. The area under the curve of Th17/Treg was the largest, and there were statistically significant differences, compared with the other three indexes (P<0.05). Conclusion: Serum IL-17, Th17 and Treg are closely related to lung function in patients with AECOPD. They can be used as important indicators for judgement of the condition and prognosis. Besides, the diagnostic efficiency of Th17/Treg is the highest.
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[1] 申永春,文富强.2018年慢性阻塞性肺疾病全球创议更新解读[J].中国实用内科杂志,2018,38(5):443~445.
[2] 唐启亚,钟小宁.中性粒细胞外诱捕网在慢性阻塞性肺部疾病免疫发病机制中的研究进展[J].医学研究生学报,2018,31(8):91~95.
[3] 张兰英,陈杰,张奕,等.慢性阻塞性肺疾病患者肺组织中树突状细胞、辅助性T细胞17/调节性T细胞的表达及其意义[J].中华内科杂志,2019,58(2):125~132.
[4] 林先刚,谭丽,黄威,等.姜黄素对慢性阻塞性肺疾病大鼠辅助性T细胞17与调节性T细胞的调节作用[J].北京中医药大学学报,2017,40(1):31~35.
[5] Ming Z,Cheng Yun-Jiu,Zheng Wei-ping,et al.Impact of chronic obstructive pulmonary disease on long-term outcome in patients with coronary artery disease undergoing percutaneous coronary intervention[J].BioMed Res Int,2016,30(11):1~6.
[6] Castiglia D,Battaglia,Salvatore,Benfante,Alida,et al.Pharmacological management of elderly patients with asthma-chronic obstructive pulmonary disease overlap syndrome:room for speculation[J].Drugs Aging,2016,33(6):375~385.
[7] Mcnicholas W T,Mcnicholas W T.Chronic obstructive pulmonary disease and obstructive sleep apnoea-the overlap syndrome.[J].Thorac Dise,2016,8(2):236~242.
[8] 杨鑫娜,刘晓菊,赵兰婷,等.Notch信号通路在慢性阻塞性肺疾病免疫失衡中的作用及机制研究[J].中华结核和呼吸杂志,2016,39(11):881~885.
[9] 汪露,江涛.外周血Th17细胞对慢性阻塞性肺疾病症状严重程度及预后的评估价值[J].中国病理生理杂志,2016,32(2):273~277. |
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2020, Vol. 26 
