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| Comparative Study on Immunoglobulin, Complement Levels and Immunopathology in Patients with Primary Glomerular Disease |
| LI Qiang, HU Guicai, SUN Nan |
| Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the relationship between immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) in renal pathology and serum immunoglobulin and complement values, so as to provide scientific basis for assistant diagnosis of primary glomerular diseases. Methods: 332 patients with IgAN and MN, 85 in IgAN group and 247 in MN group were enrolled in our hospital. The blood biochemical and pathological indexes were measured respectively, and the results were compared. Results: The intensity of complement C3 pathological immune complex in IgAN group was stronger than that in MN group (P<0.01), and the deposition level of IgG pathological immune complex was weaker than that in MN group (P<0.01). The sIgA and sIgG values in IgAN group were higher than those in MN group (P<0.01, P<0.01), and the values of sC3 and sC4 were lower than those in MN group (P<0.01, P<0.01). The levels of BUN and SCR in IgAN group were higher than those in MN group (P<0.01, P<0.05). The levels of sC3 and sC4 in MN group were negatively correlated with the intensity of C3 pathological immune complex (P<0.05, P<0.05); the levels of sC3 in MN group were negatively correlated with the intensity of C3 pathological immune complex (P<0.05); the levels of Scr and sIgA in IgAN group were negatively correlated with the intensity of IgG (P<0.05, P<0.05); the levels of sIgG in MN group were negatively correlated with the intensity of IgG (P<0.05). Conclusion: There are differences in immunoglobulin, complement pathology and serological levels in patients with IgAN and MN, and their manifestations are different in different diseases. Immunoglobulin, complement pathology and serological levels are closely related to IgAN and MN. Therefore, the intensity of pathological grade can be predicted by monitoring serological indicators.
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2019, Vol. 25 
