胃癌患者血清miR-183 E-selectin AMBP的变化及与临床病理的关系

doi:10.3969/j.issn.1006-6233.2019.12.044

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Abstract Objective: To analyze the changes of serum Microrna-183(mir-183), E-selectin and α1-microglobulin/precursor trypsin inhibitor (AMBP) in patients with gastric cancer and their relationship with clinical pathology. Methods: 96 patients with gastric cancer who treated from January 2016 to January 2017 in our hospital and 30 patients with outpatient health examination were selected at the same time. Then serum levels of miR-183, E-selectin and AMBP between the gastric cancer group and the control group were compared, and the correlation between the above indicators and clinical pathology was analyzed, and the predictive value of gastric cancer diagnosis was also analyzed. Results: Serum levels of miR-183, E-selectin and AMBP in gastric cancer group were higher than the control group, there were a statistically significant difference (P<0.05).The levels of miR-183, E-selectin and AMBP in serum of patients with different TNMⅢ-Ⅳ stages, lymph node metastasis and infiltration depth T3-T4 were higher than those of patients with TNM-Ⅱ stages, no lymph node metastasis and infiltration depth T1-T2, with statistical difference (P<0.05). Serum miR-183, E-selectin and AMBP levels showed no difference among different ages, genders, tumor distribution sites, HP infection and tumor differentiation (P>0.05). The area under the curve of miR-183 was 0.687, and the sensitivity and specificity were 0.833 and 0.625; The area under the E-selectin curve was 0.854, and the sensitivity and specificity were 0.831 and 0.829;The area under the AMBP curve was 0.752, and the sensitivity and specificity were 0.867 and 0.635;The area under the curve was 0.908, and the sensitivity and specificity were 0.900 and 0.843. Conclusion: Serum levels of miR-183, E-selectin and AMBP are correlated with the clinical pathology of gastric cancer, it can also facilitate the diagnosis of gastric cancer, combined monitoring can make up for the deficiency of single index and has high clinical application value.

Key words： Gastric cancer Microrna-183 E-selectin α1-microglobulin/precursor trypsin inhibitor Clinical pathology

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.12.044 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I12/2094

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