肾透明细胞癌中KIF2A LSD1 蛋白表达的相关性研究

doi:10.3969/j.issn.1006-6233.2019.12.032

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Abstract Objective: To explore the relationship KIF2A LDS and the occurrence, development and biological behavior of RCCC by detecting the protein expression of KIF2A and LSD1 in renal clear cell carcinoma (RCCC) and adjacent non tumor tissues,. Methods: The expression of KIF2A and LSD1 in 120 cases of renal clear cell carcinoma and 40 cases of adjacent non-tumor tissues to renal clear cell carcinoma were detected by immunohistochemistry. Results: The expression of KIF2A in renal clear cell carcinoma (60.83%) was significantly higher than that in non-tumor tissues (32.5%). The difference was statistically significant (P<0.05). The expression of LSD1 in renal clear cell carcinoma (55.0%) was significantly higher than that in non-tumor tissues (30.0%). The difference was statistically significant (P<0.05). The expression of KIF2A in RCCC was significantly higher than that in who / ISUP pathological grade and clinical significance The expression of LSD1 protein in RCCC was correlated with WHO / ISUP pathological grade (P<0.05), but not with clinical stage (P > 0.05). The expression of KIF2A and LSD1 protein was not correlated with gender and age (P > 0.05). The results of correlation test showed that the expression of KIF2A and LSD1 was positively correlated (rs = 0.235, P = 0.010). Conclusion: KIF2A and LSD1 may be involved in the occurrence and development of RCCC and have synergistic effect.

Key words： RCCC KIF2A LSD1 Immunohistochemical

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.12.032 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I12/2049

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