|
|
Effect of Octreotide combined with Alprostadil in the Treatment of Hyperlipidemic Acute Pancreatitis and the Effect on Gastrointestinal Function Recovery and Negative Conversion Rate of Blood Amylase |
YE Dan, KE Li, ZHANG Chuan, et al |
Third People's Hospital of Chengdu, Sichuan Chengdu 610031, China |
|
|
Abstract Objective: To observe the curative effect of octreotide combined with alprostadil in the treatment of hyperlipidemic acute pancreatitis (HAP) and the effect on gastrointestinal function recovery and negative conversion rate of blood amylase. Methods: A total of 100 patients with HAP admitted to the hospital from May 2016 to May 2019 were selected and divided into 2 groups by the random number table method, 50 cases in each group. Both groups were given standardized medical treatment after admission. The control group was treatment with intravenous infusion of alprostadil and the observation group was additionally treated with continuous intravenous infusion of octreotide for 10 days. The negative conversion rates of blood amylase after 5 days and 10 days of treatment, gastrointestinal function recovery, time for blood amylase recovery, length of hospital stay, levels of serum triglyceride (TG), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), C-reactive protein (CPR) and blood rheological indicators were compared between the two groups. The incidence of complications in both groups was recorded. Results: For mild patients, the total response rate of the observation group was significantly higher than that of the control group. The negative conversion rate of blood amylase in the observation group after 5 days of treatment was significantly higher than that in the control group (P<0.05). However, for severe patients, there was no significant difference in the total response rate or the negative conversion rate of blood amylase between the two groups (P>0.05). The time for gastrointestinal function recovery and blood amylase recovery in the observation group was significantly shorter than that in the control group. The length of hospital stay was also significantly shorter than the control group (P<0.05). The levels of TG, IL-6, TNF-α, CRP and blood rheological indicators in both groups were decreased significantly after treatment, and the levels were lower in the observation group than the control group (P<0.05). The incidence of complications in the observation group was significantly lower than that in the control group (8.00% vs 22.00%) (P<0.05). Conclusion: Octreotide combined with alprostadil can effectively reduce levels of blood lipids in patients with HAP, promote gastrointestinal function recovery, increase the negative conversion rate of blood amylase, reduce inflammation and improve the status of blood microcirculation, with high safety.
|
|
|
|
|
[1] 王迪,赵海平,胡文秀,等.高脂血症性胰腺炎研究进展[J].中国临床研究,2017,30(9):1275~1279. [2] 蒋晓岚,杨帆,王春晖,等.高脂血症性急性胰腺炎血清细胞因子水平与病情严重程度的相关性[J].西部医学,2017,29(4):489~493. [3] 左丽婷,陈建,张海蓉.高脂血症性胰腺炎的研究进展[J].中国全科医学,2017,20(9):1141~1146. [4] 孙备,李乐.急性胰腺炎的诊断与评估-基于亚特兰大分类标准修订版共识的解读[J].中华外科杂志,2014,52(2):85~88. [5] 马江辰,保志军.高脂血症性急性胰腺炎发病机制的研究进展[J].国际消化病杂志,2017,37(1):24~27. [6] 黄桔秀,章赛军,阮潇潇,等.高脂血症性及非高脂血症性急性胰腺炎患者的临床特点与C-反应蛋白对其严重程度的评估[J].中华医院感染学杂志,2018,28(6):893~895. [7] 赵志伶,王芳,孟超,等.血脂水平对高脂血症性急性胰腺炎严重性的影响[J].中国中西医结合急救杂志,2018,25(4):379~382. [8] 李敏利,张晓华,金鑫鑫,等.前列地尔对重症急性胰腺炎患者早期促炎因子的影响及疗效观察[J].解放军医学杂志,2017,42(2):140~143. [9] 高改云,李静,樊宏伟,等.小剂量奥曲肽预防内镜逆行胰胆管造影术后高淀粉酶血症及急性胰腺炎的临床观察[J].中国药房,2017,28(8):1095~1097. [10] 朱守朝,何建,章德文.奥曲肽对急性胰腺炎患者的临床疗效及对血液流变学、血清炎症因子的影响[J].贵州医药,2017,41(5):488~490. |
|
|
|