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| Effect of Amifostine combined with GP Regimen on the Short-term Efficacy and Adverse Reactions of Chemotherapy in Patients with Advanced Breast Cancer |
| QIN Xuejin, HAN Ke |
| Fuyang Hospital Affiliated to Anhui Medical University, Anhui Fuyang 236000, China |
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Abstract Objective: To analyze the effect of amifostine combined with gemcitabine + cisplatin (GP) regimen on short-term efficacy and adverse reactions of chemotherapy in patients with advanced breast cancer. Methods: The clinical data of 66 patients with advanced breast cancer diagnosed by pathology and cytology from July 2017 to December 2018 were analyzed retrospectively. 66 patients were divided into control group (30 cases) receiving GP treatment and combined group (36 cases) treated by amifostine combined with GP. The short-term efficacy and adverse reactions of chemotherapy were compared between the two groups. Results: There was no significant difference in total effective rate and disease control rate between the two groups (both P> 0.05). There was no significant difference in the incidence of nausea, vomiting, dizziness, liver dysfunction and renal dysfunction between the two groups (all P>0.05), but the incidence rate of peripheral neurotoxicity and myelosuppression in the combined group was significantly lower than that in the control group (both P<0.05). Conclusion: The short-term efficacy of amifostine combined with GP regimen in the treatment of advanced breast cancer is similar to that of GP regimen alone, but amifostine combined with GP regimen can effectively decrease the incidence rate of peripheral nerve toxicity and myelosuppression, and does not cause serious adverse reactions of chemotherapy, with good tolerance of patients.
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2019, Vol. 25 
