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| Effect of Different Doses of Dizosin Under BIS Monitoring in Patients undergoing General Anesthesia for Laparoscopic Surgery |
| WANG Fang |
| Liaoyang Central Hospital, Liaoning Liaoyang 111000, China |
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Abstract Objective: To observe the effect of different dosages of dizocine in patients undergoing general anesthesia during laparoscopic surgery under BIS monitoring. Methods: 76 patients undergoing elective laparoscopic surgery in our hospital from February 2017 to May 2018 were prospectively selected and randomly divided into two groups according to the digital random table method. The low dose group (38 cases) was given 0.10 mg/kg of dizosin combined with propofol, and the high dose group (38 cases) was given 0.15 mg/kg of dizosin combined with propofol. The changes of hemodynamics, time index, propofol dosage, incidence of restlessness and adverse reactions during anesthesia were compared between the two groups. Results: In hemodynamic indexes, MAP, HR and SpO2 were decreased in both groups compared with T0 (t=13.818、6.059、12.821、4.775、33.466、12.903,P<0.05). T2 and T1 MAP, HR, SpO2 increased (t=6.539、5.695、4.060、3.089、29.878、15.137,P<0.05). Group 2 sets of patient groups, the high dose group T1, T2 has a significantly higher SpO2 than the simultaneous low dose group (t=12.821、3.627,P<0.05). 2 groups of patients in the induction time, awake time and directional force recovery time time on indicators had no significant difference (P＞0.05). But high doses of propofol are significantly lower than the low dose group (t=8.256,P＜0.05). There was no significant difference in the incidence of early agitation and adverse reflux rate between the two groups (P＞0.05). Conclusion: Dizosin can effectively control hemodynamics, alleviate stress response and reduce the dosage of propofol, while 0.1 mg/kg of Dizosin can effectively reduce the incidence of restlessness with fewer adverse reactions.
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[1] Frederick H J, Wofford K, De L D G, et al. A randomized controlled trial to determine the effect of depth of anesthesia on emergence agitation in children[J]. Anesthesia & Analgesia, 2016, 122(4):1141~1146.
[2] 郭飞,宋杰.双侧腹横肌平面罗哌卡因阻滞对腹腔镜胆囊切除患者术后呼吸功能和疼痛的影响[J].江苏医药,2016,42(13):1496~1498.
[3] Saccardi C , Gizzo S , Vitagliano A , et al. Peri-incisional and intraperitoneal ropivacaine administration: a new effective tool in pain control after laparoscopic surgery in gynecology: a randomized controlled clinical trial[J]. Surgical Endoscopy, 2016, 30(12):5310~5318.
[4] 苏晓华,苏红,蔡巧颖,等.全身麻醉联合硬膜外麻醉在老年患者手术中的应用[J].医学研究与教育,2016,33(3):10~15.
[5] 乐园,李杨,苏勋玲,等.BIS监测下丙泊酚靶控静脉麻醉与七氟醚麻醉效果比较简[J].现代生物医学进展,2016,16(27):5380~5382.
[6] Wu Y X, Wu C S, Hong F Y, et al. Effect of different doses of dezocine on recovery quality from general anesthesia in patients undergoing laparoscopic surgery[J]. World Chinese Journal of Digestology, 2017, 25(3):298.
[7] 郑彬,佘守章.地佐辛在麻醉镇痛领域的应用进展[J].广东医学,2015,36(21):3266~3268. |
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2019, Vol. 25 
