|
|
|
| Curative Efficacy of Articular Cavity Injection of Sodium Lyaluronate and Ropivacaine combined with Arthroscopic Debridement in treatment of Osteoarthritis of the Knee |
| WU Ye,TAO Zhongliang, LI Jun, et al |
| Xuancheng People's Hospital, Anhui Xuancheng 242000, China |
|
|
|
|
Abstract Objective: To study curative efficacy of Articular cavity injection of sodium hyaluronate and ropivacaine combined with arthroscopic debridement in treatment of Osteoarthritis of the knee. Methods: 100 cases of knee osteoarthritis patients admitted to our hospital from February 2016 to February 2018 were selected as the research objects,randomized number table method was used to divide the observation group (n=51) and the control group (n=49). The control group was treated with arthroscopic debridement, and the observation group was treated with sodium hyaluronate injection and ropivacaine combined with arthroscopic debridement. After treatment, the efficacy, inflammatory indexes [interleukin-1 beta (il-1), tumor necrosis factor alpha (tnf-alpha), interleukin-6 (il-6)], knee joint function score (HSS), visualanalogue scale of pain (VAS), postoperative recovery time and quality of life of the two groups were compared. Results: After treatment, the excellent and good rates of patients in the two groups were 84.31% and 65.31% respectively, with statistically significant difference (P < 0.05). There was no significant difference in pre-treatment inflammatory index between the two groups. After treatment, the levels of inflammatory indexes in both groups were significantly decreased, and the levels of il-1 beta, tnf-alpha and il-6 in the observation group were significantly lower than those in the control group (P < 0.05). There was no significant difference in VAS and HSS scores between the two groups before treatment. After treatment, VAS score in both groups decreased significantly, and HSS score in the observation group was significantly higher than that in the control group, and VAS score was significantly lower than that in the control group (P < 0.05). After treatment, the postoperative recovery time of the observation group was significantly lower than that of the control group, and the quality of life score was significantly higher than that of the control group (P < 0.05). Conclusion: Intra-articular injection of sodium hyaluronate and ropivacaine combined with arthroscopic debridement in patients with knee osteoarthritis has a significant effect, which can effectively improve the knee function and inflammatory index level of patients, and is worthy of promotion and application.
|
|
|
|
|
|
[1] 杨勇,赵良虎,黄金.膝关节置换术结合中药疗法对膝关节骨性关节炎的临床疗效研究[J].中国骨质疏松杂志,2016,22(7):837~841.
[2] 卢颖.膝关节骨性关节炎患者关节镜清理术后药物辅助治疗的临床应用效果[J].中国内镜杂志,2018,24(11):62~66.
[3] Fatimah N, Salim B, Raja E U H, et al. Predictors of response to intra-articular steroid injections in patients with osteoarthritis of the knee joint[J]. Clinical Rheumatology, 2016, 35(10):1~7.
[4] Nakagawa K, Maeda M. Associations of knee muscle force, bone malalignment, and knee-joint laxity with osteoarthritis in elderly people[J]. Journal of Physical Therapy Science, 2017, 29(3):461~464.
[5] 蔡立民,谭至超,张斌山.关节镜清理术结合中药治疗早中期膝关节骨性关节炎的疗效研究[J].广州中医药大学学报,2014,31(6):898~901.
[6] Rosenberg J H, Rai V, Dilisio M F, et al. Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint.[J]. Molecular & Cellular Biochemistry, 2017, 436(1~2):59~69.
[7] 崔卫国,邱宗雨,杨静会,等.玻璃酸钠注射与灌洗分别联合关节镜清理术治疗膝骨性关节炎的疗效及安全性对比分析[J].解放军预防医学杂志,2018,36(6):742~745.
[8] 宋敬锋,柴宏伟,孙晓新,等.关节镜清理术联合药物注射对膝骨关节炎患者疼痛症状、膝关节功能和细胞因子的影响[J].解放军医学杂志,2018,30(4):57~60. |
|
|
|
2019, Vol. 25 
