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| Application of Benazepril in Maintenance Hemodialysis Patients and Its Effect on Insulin Resistance and Lipid Metabolism Disorder |
| XUE Hui, YAN Xiaohui, LIANG Lei, et al |
| Shaanxi People's Hospital, Shaanxi Xi'an 710068, China |
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Abstract Objective: To study application of benazepril in maintenance hemodialysis patients and its effects on insulin resistance and lipid metabolism disorder. Methods: 85 patients who underwent maintenance hemodialysis in our hospital from March 2015 to March 2017 were selected for the study, the randomized table was divided into the observation group (n=45) and the control group (n=40). The control group was treated with maintenance hemodialysis, and the observation group was treated with benazepril on the basis of the control group. The changes of fasting insulin (FINS), insulin resistance index (homa-ir), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (ldl-c), high-density lipoprotein cholesterol (hdl-c), connective tissue growth factor (CTGF), endothelin-1 level and adverse reactions were compared between the two groups after treatment. Results: Before treatment, there was no significant difference in the level of FINS and homa-ir between the two groups. After treatment, the levels of females and homa-ir in both groups significantly decreased, and the levels of FINS and homa-ir in the observation group were significantly lower than those in the control group (P < 0.05). Before treatment, there was no significant difference in serum lipid level between the two groups. After treatment, serum lipid levels of both groups increased, and HDL-C decreased. TC, TG and ldl-c levels of the observation group were significantly lower than those of the control group (P < 0.05). There was no statistically significant difference in HDL-C level (P>0.05). Before treatment, there was no significant difference in serum CTGF and et-1 level between the two groups. After treatment, the serum CTGF and et-1 levels of both groups were significantly decreased, and the serum CTGF and et-1 levels of the observation group were significantly lower than those of the control group (P<0.05). The total incidence of dizziness, diarrhea, hypotension and hyperkalemia in the two groups was 8.89% and 22.50%, respectively, without significant difference (P>0.05). Conclusion: Benazepril is effective in the treatment of maintenance hemodialysis patients, which can effectively improve insulin resistance and lipid metabolism disorders, and is worthy of clinical application.
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2019, Vol. 25 
