肝肠钙粘蛋白及肿瘤标志物联合检测对胃癌分期的评估价值及与临床病理特征的关系

doi:10.3969/j.issn.1006-6233.2019.09.004

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Abstract Objective: To analyze the value of detection of hepatoenteral calcoprotein(CDH17) combined with tumor markers in the evaluation of gastric cancer staging and its relationship with clinicopathological features. Methods: 147 patien ts with gastric cancer who according to the standard of TNM staging gastric carcinoma was divided into 8 cases of stage Ⅰperiod, 13 cases of Ⅱperiod, 57 cases of Ⅲ period, 69 cases of Ⅳ period; At the same time, 171 patients with benign gastric lesions and 130 healthy patients were selected as the control group. serum CDH17 and tumor marker levels, positive tissue expression rates in each group were compared,serum CDH17 and tumor markers of each group were compared, and their diagnostic value for gastric cancer staging was also compared. Results: CDH17 and serum tumor marker levels in gastric cancer group were higher than that of benign gastric lesion group, gastric benign lesion group were higher than the control group, there was a statistically significant difference (P<0.01). CDH17 area under the curve was 0.597, CEA area under the curve was 0.508, CA50 area under the curve was 0.689, the area under the curve was CA199, CA242 0.601 area under the curve was 0.553, CA724 area under the curve was 0.725, combined determination of area under the curve was 0.810, the joint detection area under the curve was higher than a single index. Conclusion: The expression of CDH17 and tumor markers in gastric cancer is correlated with the stage of gastric cancer, which is helpful for the diagnosis of gastric cancer and the evaluation of malignant biological behavior. The combined monitoring can make up for the deficiency of individual indicators and has high clinical application value.

Key words： Gastric cancer stage Hepatoenteral calcoprotein Tumor markers

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	ZHAO Ning
	MA Wei

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ZHAO Ning,MA Wei. Assessment Value of Combined Detection of Hepatointestinal Calcoprotein and Tumor Markers in Staging of Gastric Cancer and its Relationship with Clinicopathological Features[J]. HeBei Med, 2019, 25(9): 1422-1426.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.09.004 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I9/1422

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